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Proteintech
CD206 Polyclonal Antibody
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Product Details
32647-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CD206 fusion protein Eg0790
Conjugate
Form
Liquid
Concentration
550 µg/mL
Amount
82.5 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Sequence of this protein is as follows: RQFLIYNEDH KRCVDALSAI SVQTATCNPE AESQKFRWVS DSQIMSVAFK LCLGVPSKTD WASVTLYACD SKSEYQKWEC KNDTLFGIKG TELYFNYGNR QEKNIKLYKG SGLWSRWKVY GTTDDLCSRG YEAMYSLLGN ANGAVCAFPF KFENKWYADC TSAGRSDGWL WCGTTTDYDK DKLFGFCPLH FEGSERLWNK DPLTGILYQI NSKSALTWHQ ARASCKQQNA DLLSVTEIHE QMYLTGLTSS LSSGLWIGLN SLSVRSGWQW AGGSPFRYLN WLPGSPSSEP GKSCVSLNPG KNAKWENLEC VQKLGYICKK GNNTLNPFII PSASDVPTGC PNQWWPYAGH CYRIHREEKK IQKYALQACR KEGGDLASIH SIEEFDFIFS QLGYEPNDEL WIGLNDIKIQ MYFEWSDGTP VTFTKWLPGE PSHENNRQED CVVMKGKDGY WADRACEQPL GYICKMVSQS HAVVPEGADK GCRKGWKRHG FYCYLIGSTL STFTDANHTC TNEKAYLTTV EDRYEQAFLT SLVGLRPEKY FWTGLSDVQN KGTFRWTVDE QVQFTHWNAD MPGRKAGCVA MKTGVAGGLW DVLSCEEKAK FVCKHWAEGV TRPPEPTTTP EPKCPENWGT TSKTSMCFKL YAKGKHEKKT WFESRDFCKA IGGELASIKS KDEQQVIWRL ITSSGSYHEL FWLGLTYGSP SEGFTWSDGS PVSYENWAYG EPNNYQNVEY CGELKGDPGM SWNDINCEHL NNWICQIQKG KTLLPEPTPA PQDNPPVTAD GWVIYKDYQY YFSKEKETMD NARAFCKKNF GDLATIKSES EKKFLWKYIN KNGGQSPYFI GMLISMDKKF IWMDGSKVDF VAWATGEPNF ANDDENCVTM YTNSGFWNDI NCGYPNNFIC QRHNSSINAT AMPTTPTTPG GCKEGWHLYK NKCFKIFGFA NEEKKSWQDA RQACKGLKGN LVSIENAQEQ AFVTYHMRDS TFNAWTGLND INAEHMFLWT AGQGVHYTNW GKGYPGGRRS SLSYEDADCV VVIGGNSREA GTWMDDTCDS KQGYICQTQT DPSLPVSPTT TPKDGFVTYG KSSYSLMKLK LPWHEAETYC KDHTSLLASI LDPYSNAFAW MKMHPFNVPI WIALNSNLTN NEYTWTDRWR VRYTNWGADE PKLKSACVYM DVDGYWRTSY CNESFYFLCK KSDEIPATEP PQLPGKCPES EQTAWIPFYG HCYYFESSFT RSWGQASLEC LRMGASLVSI ETAAESSFLS YRVEPLKSKT NFWIGMFRNV EGKWLWLNDN PVSFVNWKTG DPSGERNDCV VLASSSGLWN NIHCSSYKGF ICKMPKIIDP VTTHSSITTK ADQRKMDPQP KGSSKA
Target Information
CD206 (MSR, Mannose receptor, MRC1) is a 175 kDa transmembrane protein belonging to the group of pattern recognition receptors. CD206 is predominantly expressed in tissue macrophages, dendritic cells, a subpopulation of endothelial cells and sperm cells. CD206 is thought to play a role in the innate and adaptive immune response. CD206 is also expressed on microglia and mato cells of the brain but not astrocytes or neurons. CD206 also mediate the recognition and uptake of a variety of macromolecules, including modified lipoproteins, advanced glycation end (AGEs) products and amyloid b-protein (Abeta). While the normal role of CD206 is associated with cell adhesion and host defense mechanisms, it also has been implicated in the development of atherosclerosis and Amyloid beta deposition in Alzheimer's disease (AD). CD206's gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. CD206 has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. Other diseases associated with CD206 dysfunction include leprosy and Gaucher's Disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD206; Macrophage mannose receptor 1; MMR
Gene Aliases: AW259686; CD206; MR; Mrc1
UniProt ID: (Mouse) Q61830
Entrez Gene ID: (Mouse) 17533, (Rat) 291327
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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