Mouse anti Sheep CD230 (Prpsc) antibody, clone ROS-BH1 recognizes the prion disease form of prion protein known as CD230.
Human prion protein (PrP), also known as PRNP, is a ubiquitously expressed GPI-anchored cell surface glycoprotein associating with lipid raft components and functioning as a signaling molecule. PrP plays a role in apoptosis in a cell context-dependent manner, is involved in proliferation of epithelial cells and in distribution of junction-associated proteins in human enterocytes. Conversion of this normal cellular prion protein (PrPc) into an abnormal conformer (PrPSc) is the crucial step associated with triggering the pathogenesis of the prion neurodegenerative disorders, such as the Creutzfeld-Jakob disease (CJD). Whereas PrPc is rich in alpha-helices, the PrPSc form has higher content of beta-sheets and is resistant to proteinase K.
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Protein Aliases: BSE; CD230; Major prion protein; MGC26679; PK resistant core; prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia); PrP; PrPc; TSE
Gene Aliases: PRNP; PRP; PRPC; SIP
UniProt ID: (Sheep) P23907
Entrez Gene ID: (Sheep) 493887