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Proteintech

CD24 Polyclonal Antibody

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View all (100) CD24 antibodies

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CD24 Polyclonal Antibody

Product Details

10600-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
View 2 publications 2 publications

Immunohistochemistry (IHC)

-
View 3 publications 3 publications

Immunocytochemistry (ICC/IF)

-
View 2 publications 2 publications
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CD24 Fusion Protein Ag0654 (1-80 aa encoded by BC007674)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.17 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MGRAMVARL GLGLLLLALL LPTQIYSSET TTGTSSNSSQ STSNSGLAPN PTNATTKAAG GALQSTASLF VVSLSLLHLY S (1-80 aa encoded by BC007674)

Target Information

CD24 is a 35-50 kDa glycosylphosphatidylinositol (GPI)-anchored glycoprotein expressed on a variety of cell types, including erythrocytes, thymocytes, peripheral lymphocytes, and cells of the myeloid lineage. It is variably glycosylated, resulting in heterogeneity in molecular mass across different cell lineages, which can affect antibody staining levels on lymphocyte populations. In the context of B-cell development, CD24 is expressed from the pro-B-cell stage in the bone marrow through to mature, surface Ig-positive B cells, with very low or negative expression on plasma cells. It is also present on the majority of B-lineage acute lymphoblastic leukemias, B-cell chronic lymphocytic leukemias (CCLs), and B-cell non-Hodgkin's lymphomas. CD24 is thought to play a role in regulating B-cell proliferation and maturation, as well as in controlling autoimmunity. Additionally, CD24 has been reported to interact with P-selectin (CD62P), indicating a potential role in cell adhesion and signaling. CD24 is a valuable marker for studying B-cell development, leukemia, lymphoma, and autoimmune regulation, as well as its interactions with other molecules like P-selectin.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: CD24; CD24 antigen; CD24 antigen (small cell lung carcinoma cluster 4 antigen); cluster of differentiation 24; FLJ22950; FLJ43543; heat stable antigen; Heat-stable antigen; HSA; Ly-52; Lymphocyte antigen 52; M1/69-J11D heat stable antigen; MGC75043; Nectadrin; nectadrin heat stable antigen; R13-Ag; Signal transducer CD24; Small cell lung carcinoma cluster 4 antigen; X62 heat stable antigen

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Gene Aliases: CD24; CD24A; HSA; Ly-52; nectadrin

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UniProt ID: (Human) R4I4T5, (Rat) Q07490, (Mouse) P24807

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Entrez Gene ID: (Human) 100133941, (Rat) 25145, (Mouse) 12484

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Function(s)
signal transducer activity protein binding protein kinase binding protein tyrosine kinase activator activity carbohydrate binding
Process(es)
response to hypoxia cell activation regulation of cytokine-mediated signaling pathway response to molecule of bacterial origin pre-B cell differentiation leukocyte migration involved in inflammatory response positive regulation of T cell mediated immune response to tumor cell positive regulation of inflammatory response to antigenic stimulus positive regulation of B cell apoptotic process cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules leukocyte cell-cell adhesion cell surface receptor signaling pathway positive regulation of cytosolic calcium ion concentration neuromuscular synaptic transmission negative regulation of neuroblast proliferation apoptotic mitochondrial changes positive regulation of neuron projection development cell migration regulation of cell-cell adhesion positive regulation of cell-cell adhesion apoptotic nuclear changes negative regulation of B cell proliferation neuron projection development T cell costimulation chemokine receptor transport out of membrane raft negative regulation of transforming growth factor beta3 production positive regulation of integrin activation positive regulation of cell adhesion mediated by integrin regulation of cell-cell adhesion mediated by integrin positive regulation of cell-cell adhesion mediated by integrin negative regulation of erythrocyte clearance homotypic cell-cell adhesion negative regulation of erythrocyte aggregation positive regulation of T cell homeostatic proliferation positive regulation of activated T cell proliferation regulation of phosphorylation cholesterol homeostasis positive regulation of MAP kinase activity regulation of MAPK cascade response to estrogen regulation of B cell differentiation negative regulation of neuron differentiation respiratory burst negative regulation of T cell homeostatic proliferation positive regulation of alpha-beta T cell proliferation synaptic vesicle endocytosis positive regulation of peptidyl-tyrosine phosphorylation negative regulation of neurogenesis positive regulation of calcium-mediated signaling positive regulation of protein tyrosine kinase activity apoptotic signaling pathway immune response-regulating cell surface receptor signaling pathway Wnt signaling pathway single organismal cell-cell adhesion regulation of epithelial cell differentiation B cell receptor transport into membrane raft glomerular visceral epithelial cell differentiation glomerular parietal epithelial cell differentiation intrinsic apoptotic signaling pathway positive regulation of nephron tubule epithelial cell differentiation immune response cell-cell signaling
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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