Invitrogen

CD24 Monoclonal Antibody (SN3), PE-Alexa Fluor™ 610

Product Details

MHCD2422

Applications	Tested Dilution	Publications
Flow Cytometry (Flow)	Assay-Dependent	View 3 publications 3 publications
Miscellaneous PubMed (Misc)	-	View 1 publication 1 publication

Product Specifications
Species Reactivity	Human
Published species	Human, Mouse
Host/Isotype	Mouse / IgG1
Class	Monoclonal
Type	Antibody
Clone	SN3
Immunogen	Human CD24
Conjugate	PE-Alexa Fluor™ 610 FITC PE
Excitation/Emission Max	567/627 nm View spectra
Form	Liquid
Purification	purified
Storage buffer	PBS with BSA, 10% sucrose
Contains	0.1% sodium azide
Storage conditions	4° C, store in dark
RRID	AB_10375871

Product Specific Information

The R-phycoerythrin (PE)-Cy7® tandem conjugate permits simultaneous multicolor labeling and detection of multiple targets with excitation by a 488 nm laser without occupying traditional channels associated with FITC and PE.

Target Information

CD24 is a two-chain glycosylphosphatidylinositol (GPI)-anchored glycoprotein expressed at multiple stages of B-cell development, beginning with the bone marrow pro-B-cell compartment and continuing through mature, surface Ig positive B-cells. Plasma cell expression is very low or negative. CD24 is also expressed on the majority of B-lineage acute lymphoblastic leukemias, B-cell CCLs and B-cell non-Hodgkin's lymphomas. CD24 may play a role in regulation of B-cell proliferation and maturation, and control of autoimmunity.

Analyte Specific Reagent

Flow Cytometry

Panel Builder

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Product References

X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19.

Science immunology

Asano T,Boisson B,Onodi F,Matuozzo D,Moncada-Velez M,Maglorius Renkilaraj MRL,Zhang P,Meertens L,Bolze A,Materna M,Korniotis S,Gervais A,Talouarn E,Bigio B,Seeleuthner Y,Bilguvar K,Zhang Y,Neehus AL,Ogishi M,Pelham SJ,Le Voyer T,Rosain J,Philippot Q,Soler-Palacín P,Colobran R,Martin-Nalda A,Rivière JG,Tandjaoui-Lambiotte Y,Chaïbi K,Shahrooei M,Darazam IA,Olyaei NA,Mansouri D,Hatipoğlu N,Palabiyik F,Ozcelik T,Novelli G,Novelli A,Casari G,Aiuti A,Carrera P,Bondesan S,Barzaghi F,Rovere-Querini P,Tresoldi C,Franco JL,Rojas J,Reyes LF,Bustos IG,Arias AA,Morelle G,Christèle K,Troya J,Planas-Serra L,Schlüter A,Gut M,Pujol A,Allende LM,Rodriguez-Gallego C,Flores C,Cabrera-Marante O,Pleguezuelo DE,de Diego RP,Keles S,Aytekin G,Akcan OM,Bryceson YT,Bergman P,Brodin P,Smole D,Smith CIE,Norlin AC,Campbell TM,Covill LE,Hammarström L,Pan-Hammarström Q,Abolhassani H,Mane S,Marr N,Ata M,Al Ali F,Khan T,Spaan AN,Dalgard CL,Bonfanti P,Biondi A,Tubiana S,Burdet C,Nussbaum R,Kahn-Kirby A,Snow AL,Bustamante J,Puel A,Boisson-Dupuis S,Zhang SY,Béziat V,Lifton RP,Bastard P,Notarangelo LD,Abel L,Su HC,Jouanguy E,Amara A,Soumelis V,Cobat A,Zhang Q,Casanova JL

MHCD2422 was used in Flow Cytometry to report very rare, biochemically deleterious X-linked TLR7 variants in 16 unrelated male individuals with unexplained critical COVID-19 pneumonia.

Thu Aug 19 00:00:00 EDT 2021

Longitudinal studies of a B cell-derived signature of tolerance in renal transplant recipients.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Newell KA,Asare A,Sanz I,Wei C,Rosenberg A,Gao Z,Kanaparthi S,Asare S,Lim N,Stahly M,Howell M,Knechtle S,Kirk A,Marks WH,Kawai T,Spitzer T,Tolkoff-Rubin N,Sykes M,Sachs DH,Cosimi AB,Burlingham WJ,Phippard D,Turka LA

MHCD2422 was used in flow cytometry to assess the role of B cells in tolerant kidney transplant recipients.

Sun Nov 01 00:00:00 EDT 2015

Asporin Is a Fibroblast-Derived TGF-β1 Inhibitor and a Tumor Suppressor Associated with Good Prognosis in Breast Cancer.

PLoS medicine

Maris P,Blomme A,Palacios AP,Costanza B,Bellahcène A,Bianchi E,Gofflot S,Drion P,Trombino GE,Di Valentin E,Cusumano PG,Maweja S,Jerusalem G,Delvenne P,Lifrange E,Castronovo V,Turtoi A

MHCD2422 was used in Flow cytometry/Cell sorting to show that asporin is a stroma-derived inhibitor of TGF-β1 and a tumor suppressor in breast cancer and indicate the direction of pre-clinical studies.

Tue Sep 01 00:00:00 EDT 2015

Profiling of normal and malignant breast tissue show CD44high/CD24low phenotype as a predominant stem/progenitor marker when used in combination with Ep-CAM/CD49f markers.

BMC cancer

Ghebeh H,Sleiman GM,Manogaran PS,Al-Mazrou A,Barhoush E,Al-Mohanna FH,Tulbah A,Al-Faqeeh K,Adra CN

MHCD2422 was used in Flow cytometry/Cell sorting to demonstrate that normal and malignant breast cells with CD44high/CD24low phenotypes have the highest stem/progenitor cell ability, with Ep-CAM/CD49f reference markers.

Fri Jun 14 00:00:00 EDT 2013

Bioinformatics

Protein Aliases: CD24; CD24 antigen (small cell lung carcinoma cluster 4 antigen); FLJ22950; FLJ43543; MGC75043; Signal transducer CD24; Small cell lung carcinoma cluster 4 antigen

Gene Aliases: CD24; CD24A

UniProt ID: (Human) P25063

Entrez Gene ID: (Human) 100133941

Function(s)

response to hypoxia cell activation regulation of cytokine-mediated signaling pathway response to molecule of bacterial origin immune response-regulating cell surface receptor signaling pathway positive regulation of cytosolic calcium ion concentration Wnt signaling pathway single organismal cell-cell adhesion cell migration regulation of epithelial cell differentiation T cell costimulation B cell receptor transport into membrane raft chemokine receptor transport out of membrane raft negative regulation of transforming growth factor beta3 production positive regulation of activated T cell proliferation regulation of phosphorylation cholesterol homeostasis positive regulation of MAP kinase activity regulation of MAPK cascade response to estrogen respiratory burst positive regulation of protein tyrosine kinase activity glomerular visceral epithelial cell differentiation glomerular parietal epithelial cell differentiation intrinsic apoptotic signaling pathway positive regulation of nephron tubule epithelial cell differentiation

Process(es)

signal transducer activity protein binding protein kinase binding protein tyrosine kinase activator activity

CD24 Monoclonal Antibody (SN3), PE-Alexa Fluor™ 610

Product Details

MHCD2422

Flow Cytometry (Flow)

Miscellaneous PubMed (Misc)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Excitation/Emission Max

Form

Purification

Storage buffer

Contains

Storage conditions

RRID

Product Specific Information

Target Information

How to use the Panel Builder

Bioinformatics

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