In sandwich ELISAs, less than 2% cross-reactivity with recombinant human TWEAK R is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
TWEAK is a member of the TNF family and was first described as a weak inducer of apoptosis in demonstrate that this relatively small molecule is a fully transformed cell lines. Recently, a receptor for TWEAK was isolated by expression cloning from a HUVEC cell cDNA library. TweakR is a small protein belonging to TNF receptor super family. TweakR is capable of intiating a proliferative signal by binding to TRAF1, 2, and 3. TweakR mRNA is upregulated during tissue regeneration in the aorta and liver. It may also play a role in vascular cell migration and angiogenesis.
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Protein Aliases: CD266; FGF-inducible 14; fibroblast growth factor regulated protein 2; Fibroblast growth factor-inducible immediate-early response protein 14; Fibroblast growth factor-regulated protein 2; Tumor necrosis factor receptor superfamily member 12A; Tweak-receptor; TweakR; type I transmembrane protein Fn14
Gene Aliases: AI255180; C87282; Fgfrp2; Fn14; HPIP; Tnfrsf12a; TWEAK-R; TweakR
UniProt ID: (Mouse) Q9CR75
Entrez Gene ID: (Mouse) 27279
Molecular Function: transmembrane signal receptor