A suggested positive control is human spleen tissue lysate.
PA5-20013 can be used with blocking peptide PEP-0132.
Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF, BLyS, TALL-1, THANK, and zTNF4. BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. Two receptors, TACI and BCMA, for BAFF were originally identified. A third receptor was identified recently and designated BAFF-R and BR3 for BLyS receptor 3. Unlike BCMA and TACI, which bind to BAFF and April, BAFF-R/BR3 is specific for BAFF and plays a predominant role in BAFF induced B cell development and survival. BAFF and its receptors are involved in B cell associated autoimmune diseases, and activate NF-kappa-B and c-jun N-terminal kinase.
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Protein Aliases: B cell-activating factor receptor; B-cell maturation defect; B-cell maturation defect 1; B-cell-activating factor receptor; BAFF receptor; BAFF-R; BAFFR; BLyS receptor 3; BR3; CD268; TNFRSF13C; Tumor necrosis factor receptor superfamily member 13C; tumor necrosis factor receptor superfamily, member 13C
Gene Aliases: 2010006P15Rik; BAFF-R; BAFFR; Bcmd; Bcmd-1; Bcmd1; BR3; BROMIX; CD268; CVID4; Lvis22; prolixin; RGD1560810; TNFRSF13C