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Invitrogen

CD3/CD20 Antibody Cocktail

View all (10) CD3/CD20 antibodies

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Product Details

MA5-14433

Applications
Tested Dilution
Publications

Western Blot (WB)

Neat-1:100
-

Immunohistochemistry (Paraffin) (IHC (P))

Neat
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mixed / IgG2a, kappa

Class

Cocktail

Type

Antibody

Clone

CD3-SP7; CD20-L26

Immunogen

synthetic 13-mer peptide corresponding to aa 156-168 of the epsilon chain of human CD3 protien; CD20- Human tonsil B cells

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

purified

Storage buffer

tris HCl, pH 7.6, with proprietary stabilizer

Contains

<0.1% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10986449

Product Specific Information

MA5-14433 targets CD3/CD20 in IHC (P) and WB applications and shows reactivity with Human, Mouse and Rat samples. CD3 (clone SP7) is a rabbit monoclonal IgG antibody. CD20 (clone L26) is an IgG2a mouse monoclonal antibody.

The MA5-14433 immunogen is synthetic 13-mer peptide corresponding to aa 156-168 of the epsilon chain of human CD3 protein; the CD20 immunogen is human tonsil B cells.

Target Information

The CD3 antibody reacts with the intracytoplasmic portion of the CD3 antigen expressed by normal and neoplastic T-lymphocytes. It stains human T-lymphocytes in both cortex and medulla of the thymus and in peripheral lymphoid tissues. CD20 is a non-Ig differentiation antigen of B-lymphocytes and the expression of CD20 is restricted to normal and neoplastic B-lymphocytes, being absent from all other leukocytes and tissues. The CD3-CD20 cocktail reveals lymphoid architecture in neoplastic situations.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: B-cell differentiation antigen Ly-44; B-lymphocyte antigen CD20; B-lymphocyte cell-surface antigen B1; B-lymphocyte surface antigen B1; Bp35; CD20; CD20 antigen; CD20 receptor; CD3 antigen delta polypeptide; CD3 antigen, delta subunit; CD3 antigen, epsilon polypeptide; CD3 antigen, gamma polypeptide; CD3 delta; CD3 gamma-chain; CD3 molecule delta polypeptide; CD3 molecule, epsilon polypeptide; CD3 molecule, gamma polypeptide; CD3-epsilon; CD3d; CD3d antigen, delta polypeptide (TiT3 complex); CD3d molecule, delta (CD3-TCR complex); CD3e; CD3e antigen, epsilon polypeptide (TiT3 complex); CD3e molecule, epsilon (CD3-TCR complex); CD3g; CD3g antigen, gamma polypeptide (TiT3 complex); CD3g molecule, epsilon (CD3-TCR complex); CD3g molecule, gamma (CD3-TCR complex); Leukocyte surface antigen Leu-16; Lymphocyte antigen 44; Membrane-spanning 4-domains subfamily A member 1; membrane-spanning 4-domains, subfamily A, member 1; membrane-spanning 4-domains, subfamily A, member 2; OKT3, delta chain; T-cell antigen receptor complex, epsilon subunit of T3; T-cell antigen receptor complex, gamma subunit of T3; T-cell receptor T3 delta chain; T-cell receptor T3 gamma chain; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 delta chain; T-cell surface glycoprotein CD3 epsilon chain; T-cell surface glycoprotein CD3 gamma chain; unnamed protein product

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Gene Aliases: AA960661; AI504783; B1; Bp35; CD20; CD3; CD3-DELTA; CD3-GAMMA; CD3D; CD3DELTA; CD3E; CD3epsilon; CD3G; CD3GAMMA; Ctg-3; Ctg3; CVID5; FMC7; IMD17; IMD18; IMD19; LEU-16; Ly-44; MS4A1; Ms4a2; S7; T3D; T3E; T3G; TCRE

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UniProt ID: (Human) P04234, (Human) P07766, (Human) P09693, (Mouse) P04235, (Rat) P19377, (Mouse) P22646, (Mouse) P11942, (Rat) Q64159, (Human) P11836, (Mouse) P19437

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Entrez Gene ID: (Human) 915, (Human) 916, (Human) 917, (Mouse) 12500, (Rat) 25710, (Rat) 315609, (Mouse) 12501, (Mouse) 12502, (Rat) 300678, (Human) 931, (Rat) 309217, (Mouse) 12482

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Function(s)
transmembrane signaling receptor activity protein binding identical protein binding SH3 domain binding protein kinase binding receptor signaling complex scaffold activity T cell receptor binding protein heterodimerization activity molecular_function transcription coactivator activity signal transducer activity epidermal growth factor receptor binding immunoglobulin binding MHC class II protein complex binding transporter
Process(es)
adaptive immune response immune system process cell surface receptor signaling pathway positive thymic T cell selection alpha-beta T cell activation T cell receptor signaling pathway positive regulation of cell-matrix adhesion positive regulation of T cell anergy T cell anergy transmembrane receptor protein tyrosine kinase signaling pathway signal complex assembly G-protein coupled receptor signaling pathway smoothened signaling pathway regulation of signal transduction positive regulation of gene expression negative regulation of gene expression dendrite development calcium-mediated signaling cerebellum development T cell costimulation positive regulation of interferon-gamma production positive regulation of interleukin-2 production positive regulation of interleukin-4 production positive regulation of cell-cell adhesion mediated by integrin CD4-positive, alpha-beta T cell proliferation T cell proliferation positive regulation of T cell proliferation T cell activation regulation of apoptotic process positive regulation of MAPK cascade negative thymic T cell selection negative regulation of smoothened signaling pathway gamma-delta T cell activation lymphocyte activation positive regulation of calcium-mediated signaling positive regulation of T cell activation protein-containing complex assembly apoptotic signaling pathway positive regulation of CD4-positive, alpha-beta T cell proliferation establishment or maintenance of cell polarity protein transport regulation of lymphocyte apoptotic process protein complex assembly biological_process T cell differentiation positive regulation of transcription from RNA polymerase II promoter response to nutrient T cell differentiation in thymus positive regulation of interleukin-2 biosynthetic process positive regulation of alpha-beta T cell proliferation positive regulation of peptidyl-tyrosine phosphorylation store-operated calcium entry humoral immune response response to bacterium B cell differentiation B cell proliferation B cell activation B cell receptor signaling pathway protein tetramerization calcium ion import into cytosol positive regulation of calcium ion import across plasma membrane
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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