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Invitrogen
CD3/CD4/CD8 Antibody Cocktail, FITC, PE, TRI-COLOR™
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Product Details
CD3-4-8-A
Applications
Tested Dilution
Publications
Product Specifications
Published species
C. elegans,
Mouse
Host/Isotype
Mouse
/ IgG2a
Class
Cocktail
Type
Antibody
Immunogen
Human CDCD8
Conjugate
Form
Liquid
Storage conditions
4°C, store in dark
Shipping conditions
Wet ice
RRID
Product Specific Information
CD3 clone# S4.1, CD4 clone# S3.5, CD8 clone# 3B5
Target Information
CD8 (Cluster of Differentiation 8) is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediate efficient cell-cell interactions within the immune system. The CD8 antigen acts as a co-receptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. CD8 is found on a T cell subset of normal cytotoxic/suppressor cells which make up approximately 20-35 % of human peripheral blood lymphocytes. The CD8 antigen is also detected on natural killer (NK) cells, subpopulations of peripheral blood null cells, thymocytes and bone marrow cells. The CD8 co-receptor functions as either a homodimer composed of two alpha chains, or as a disulfide-linked heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. The majority of CD8+ T cells express CD8 as a alpha/beta heterodimer. In HIV, the HIV-2 envelope glycoprotein binds CD8 alpha chain (but not the beta chain).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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