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Invitrogen
CD3/CD44 Antibody Cocktail, FITC, PE
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Product Details
MA1-12273
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Cocktail
Type
Antibody
Clone
M2AB, 7F1
Immunogen
human thymocytes and TCR-gamma epsilon thymocytes
Conjugate
FITC , PE
FITC , PE
FITC , PE
Form
Liquid
Purification
Protein A/G
Storage buffer
PBS with 0.2% carrier protein
Contains
0.08% sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is a monoclonal mixture of FITC-conjugated CD3 (clone M2AB, isotype IgG1) and PE-conjugated CD44 (clone 7F1, isotype IgG1).
Target Information
CD44 is a transmembrane glycoprotein expressed on the surface of most cells, which serves as a receptor for hyaluronan. CD44 mediates angiogenesis, cell adhesion, proliferation and migration, it is thus important for lymphocyte activation, recirculation and homing, it can thus serve e.g. as a modulator of macrophage recruitment in response to pathogen. Although CD44 functions are essential for physiological activities of normal cells, elevated CD44 expression correlates with poor prognosis in many carcinomas, facilitating tumour growth and metastasis, antiapoptosis and directional motility of cancer cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD3 antigen, delta subunit; CD3 delta; CD3 epsilon; CD3-epsilon; CD3d antigen, delta polypeptide (TiT3 complex); CD3d molecule, delta (CD3-TCR complex); CD3e antigen, epsilon polypeptide (TiT3 complex); CD3e molecule, epsilon (CD3-TCR complex); CD3g antigen, gamma polypeptide (TiT3 complex); CD3g molecule, epsilon (CD3-TCR complex); CD3g molecule, gamma (CD3-TCR complex); CD44 molecule; CD44 molecule (Indian blood group); CD44R1; CDw44 antigen precursor; cell surface glycoprotein CD44; cell-cell and cell-matrix adhesion interaction glycoprotein isoform; cell-surface glycoprotein; chondroitin sulfate proteoglycan 8; ECMRIII; epican; extracellular matrix receptor III; FLJ18683; GP90 lymphocyte homing/adhesion receptor; HCAM; hematopoietic cell E- and L-selectin ligand; heparan sulfate proteoglycan; Hermes antigen; Hermes antigen gp90 homing receptor precursor; homing cell adhesion molecule; homing function and Indian blood group system; homing receptor; hyaluronan receptor; hyaluronan-binding protein; hyaluronate receptor; In(Lu) related-p80; Indian blood group antigen; OKT3, delta chain; PGP I; PGPI; phagocyte glycoprotein 1; phagocytic glycoprotein 1; sCD 44; sCD44; soluble CD44; T-cell antigen receptor complex, epsilon subunit of T3; T-cell antigen receptor complex, gamma subunit of T3; T-cell receptor T3 delta chain; T-cell receptor T3 gamma chain; T-cell surface antigen T3/Leu-4 epsilon chain; unnamed protein product
Gene Aliases: CD3-DELTA; CD3-GAMMA; CD3DELTA; CD3epsilon; CD3GAMMA; CDW44; CSPG8; ECM-III; ECMR-III; H-CAM; HCELL; Hermes-1; HUTCH-1; HUTCH-I; IMD17; IMD18; IMD19; LHR; MC56; MDU2; MDU3; MIC4; Pgp1; T3D; T3E; T3G; TCRE
UniProt ID: (Human) P04234, (Human) P07766, (Human) P09693, (Human) P16070
Entrez Gene ID: (Human) 915, (Human) 916, (Human) 917, (Human) 960
transmembrane signaling receptor activity
protein binding
MHC class II receptor activity
identical protein binding
SH3 domain binding
protein kinase binding
receptor signaling complex scaffold activity
protein binding, bridging
T cell receptor binding
cytokine receptor activity
collagen binding
hyaluronic acid binding
signaling receptor activity
cargo receptor activity
adaptive immune response
cell surface receptor signaling pathway
positive thymic T cell selection
alpha-beta T cell activation
T cell receptor signaling pathway
establishment or maintenance of cell polarity
protein transport
T cell activation
gamma-delta T cell activation
protein-containing complex assembly
regulation of lymphocyte apoptotic process
positive regulation of cell-matrix adhesion
transmembrane receptor protein tyrosine kinase signaling pathway
signal complex assembly
G-protein coupled receptor signaling pathway
regulation of signal transduction
positive regulation of gene expression
negative regulation of gene expression
dendrite development
cerebellum development
positive regulation of cell-cell adhesion mediated by integrin
positive regulation of T cell proliferation
regulation of apoptotic process
endocytosis
inflammatory response
cell adhesion
cell-matrix adhesion
anatomical structure morphogenesis
cell migration
cytokine-mediated signaling pathway
hyaluronan catabolic process
positive regulation of heterotypic cell-cell adhesion
negative regulation of apoptotic process
negative regulation of DNA damage response, signal transduction by p53 class mediator
wound healing, spreading of cells
cellular response to fibroblast growth factor stimulus
system development
NK T cell activation
cartilage development
positive regulation of ERK1 and ERK2 cascade
monocyte aggregation
cell-cell adhesion
positive regulation of monocyte aggregation
carbohydrate derivative transport
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
regulation of lamellipodium morphogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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