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Invitrogen

CD3/CD44 Antibody Cocktail, FITC, PE

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Product Details

MA1-12273

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Cocktail

Type

Antibody

Clone

M2AB, 7F1

Immunogen

human thymocytes and TCR-gamma epsilon thymocytes

Conjugate

FITC , PE FITC , PE FITC , PE

Form

Liquid

Purification

Protein A/G

Storage buffer

PBS with 0.2% carrier protein

Contains

0.08% sodium azide

Storage conditions

4°C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_1072009

Product Specific Information

This antibody is a monoclonal mixture of FITC-conjugated CD3 (clone M2AB, isotype IgG1) and PE-conjugated CD44 (clone 7F1, isotype IgG1).

Target Information

CD44 is a transmembrane glycoprotein expressed on the surface of most cells, which serves as a receptor for hyaluronan. CD44 mediates angiogenesis, cell adhesion, proliferation and migration, it is thus important for lymphocyte activation, recirculation and homing, it can thus serve e.g. as a modulator of macrophage recruitment in response to pathogen. Although CD44 functions are essential for physiological activities of normal cells, elevated CD44 expression correlates with poor prognosis in many carcinomas, facilitating tumour growth and metastasis, antiapoptosis and directional motility of cancer cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD3 antigen, delta subunit; CD3 delta; CD3 epsilon; CD3-epsilon; CD3d; CD3d antigen, delta polypeptide (TiT3 complex); CD3d molecule, delta (CD3-TCR complex); CD3e; CD3e antigen, epsilon polypeptide (TiT3 complex); CD3e molecule, epsilon (CD3-TCR complex); CD3g; CD3g antigen, gamma polypeptide (TiT3 complex); CD3g molecule, epsilon (CD3-TCR complex); CD3g molecule, gamma (CD3-TCR complex); CD44; CD44 antigen; CD44 molecule; CD44 molecule (Indian blood group); CD44R1; CDw44; CDw44 antigen precursor; cell surface glycoprotein CD44; cell-cell and cell-matrix adhesion interaction glycoprotein isoform; cell-surface glycoprotein; chondroitin sulfate proteoglycan 8; ECMR-III; ECMRIII; Epican; Extracellular matrix receptor III; FLJ18683; GP90 lymphocyte homing/adhesion receptor; HCAM; hematopoietic cell E- and L-selectin ligand; Heparan sulfate proteoglycan; Hermes antigen; Hermes antigen gp90 homing receptor precursor; homing cell adhesion molecule; homing function and Indian blood group system; homing receptor; HUTCH-I; hyaluronan receptor; hyaluronan-binding protein; Hyaluronate receptor; In(Lu) related-p80; Indian blood group antigen; OKT3, delta chain; PGP I; PGP-1; PGP-I; PGPI; phagocyte glycoprotein 1; Phagocytic glycoprotein 1; Phagocytic glycoprotein I; sCD 44; sCD44; soluble CD44; T-cell antigen receptor complex, epsilon subunit of T3; T-cell antigen receptor complex, gamma subunit of T3; T-cell receptor T3 delta chain; T-cell receptor T3 gamma chain; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 delta chain; T-cell surface glycoprotein CD3 epsilon chain; T-cell surface glycoprotein CD3 gamma chain; unnamed protein product

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Gene Aliases: CD3-DELTA; CD3-GAMMA; CD3D; CD3DELTA; CD3E; CD3epsilon; CD3G; CD3GAMMA; CD44; CDW44; CSPG8; ECM-III; ECMR-III; H-CAM; HCELL; Hermes-1; HUTCH-1; HUTCH-I; IMD17; IMD18; IMD19; LHR; MC56; MDU2; MDU3; MIC4; Pgp1; T3D; T3E; T3G; TCRE

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UniProt ID: (Human) P04234, (Human) P07766, (Human) P09693, (Human) P16070

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Entrez Gene ID: (Human) 915, (Human) 916, (Human) 917, (Human) 960

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Function(s)
transmembrane signaling receptor activity protein binding identical protein binding SH3 domain binding protein kinase binding receptor signaling complex scaffold activity T cell receptor binding cytokine receptor activity collagen binding hyaluronic acid binding
Process(es)
adaptive immune response immune system process cell surface receptor signaling pathway positive thymic T cell selection alpha-beta T cell activation T cell receptor signaling pathway establishment or maintenance of cell polarity protein transport T cell activation gamma-delta T cell activation protein-containing complex assembly regulation of lymphocyte apoptotic process positive regulation of cell-matrix adhesion positive regulation of T cell anergy T cell anergy transmembrane receptor protein tyrosine kinase signaling pathway signal complex assembly G-protein coupled receptor signaling pathway smoothened signaling pathway regulation of signal transduction positive regulation of gene expression negative regulation of gene expression dendrite development calcium-mediated signaling cerebellum development T cell costimulation positive regulation of interferon-gamma production positive regulation of interleukin-2 production positive regulation of interleukin-4 production positive regulation of cell-cell adhesion mediated by integrin CD4-positive, alpha-beta T cell proliferation T cell proliferation positive regulation of T cell proliferation regulation of apoptotic process positive regulation of MAPK cascade negative thymic T cell selection negative regulation of smoothened signaling pathway lymphocyte activation positive regulation of calcium-mediated signaling positive regulation of T cell activation apoptotic signaling pathway positive regulation of CD4-positive, alpha-beta T cell proliferation inflammatory response cell adhesion cell-matrix adhesion anatomical structure morphogenesis cell migration cytokine-mediated signaling pathway hyaluronan catabolic process positive regulation of heterotypic cell-cell adhesion negative regulation of apoptotic process negative regulation of DNA damage response, signal transduction by p53 class mediator wound healing, spreading of cells cellular response to fibroblast growth factor stimulus system development cartilage development positive regulation of ERK1 and ERK2 cascade monocyte aggregation cell-cell adhesion positive regulation of monocyte aggregation negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator regulation of lamellipodium morphogenesis
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