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MA5-16726 contains a monoclonal mixture of FITC-conjugated CD3 (clone #IF4, Mouse IgM) and RPE-conjugated CD45RA (clone #OX-33, Mouse IgG1). This antibody is a dual-color reagent recognizing rat CD3 and CD45RA cell surface antigens. Clone IF4 recognizes rat CD3, a cell surface antigen expressed by mature lymphocytes. Clone OX-33 recognizes rat CD45RA, a cell surface antigen expressed by B-lymphocytes.
Reconstitute with 1 mL of distilled water. After reconstitution, store product undiluted at 4°C in the dark.
For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL.
CD45 is a family of single chain transmembraneous glycoproteins consisting of at least four isoforms which share a common large intracellular domain. Their extracellular domains are heavily glycosylated. The different isoforms are produced by alternative messenger RNA splicing of three exons of a single gene on chromosome 1. CD45 is expressed on cells of the human hematopoietic lineage with the exception of mature red cells. It is not detected on differentiated cells of other tissues. It is likely that CD45 plays an important role in signal transduction, inhibition or upregulation of various immunological functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CD3 antigen delta polypeptide; CD3 antigen, epsilon polypeptide; CD3 antigen, gamma polypeptide; CD3 epsilon; CD3 gamma-chain; CD3 molecule delta polypeptide; CD3 molecule, epsilon polypeptide; CD3 molecule, gamma polypeptide; CD3d; CD3g; CD45; FLJ18683; L-CA; leucocyte common antigen; Leukocyte common antigen; leukocyte common antigen A; leukocyte common antigen B; Protein tyrosine phosphatase, receptor-type, c polypeptide; Receptor-type tyrosine-protein phosphatase C; T-cell receptor T3 delta chain; T-cell receptor T3 gamma chain; T-cell surface glycoprotein CD3 delta chain; T-cell surface glycoprotein CD3 epsilon chain; T-cell surface glycoprotein CD3 gamma chain; T200; T200 glycoprotein; TCRE
Gene Aliases: Cd3d; Cd3g; CD45; L-CA; Lca; Ptprc; RT7; T200; T3d
UniProt ID: (Rat) P19377, (Rat) Q64159, (Rat) P04157
Entrez Gene ID: (Rat) 25710, (Rat) 315609, (Rat) 300678, (Rat) 24699
Molecular Function:
cytokine receptor
defense/immunity protein
immunoglobulin receptor superfamily
receptor
hydrolase
phosphatase
protein phosphatase
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