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Invitrogen
CD3 zeta (CD247) Polyclonal Antibody
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FIGURE: 1 / 3
CD3 zeta (CD247) Antibody (PA5-70421) in WB
Western blot was performed using Anti-CD3 zeta (CD247) Polyclonal Antibody (Product # PA5-70421) and a 18 kDa band corresponding to CD3 zeta (CD247) was observed across tissue extracts tested except in Rat Heart and Rat Cerebellum which are reported to be expressing low levels of CD3 zeta. Tissue extracts (30 µg lysate) of Mouse Thymus (Lane 1), Rat Axillary Lymph node (Lane 2), Rat Heart (Lane 3), Rat Cerebellum (Lane 4) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0322BOX). Resolved proteins were then transf... View More
Product Details
PA5-70421
Product Specifications
Species Reactivity
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide directed towards the C-terminal region of rat CD3
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This target displays homology in the following species: Cow: 75%; Dog: 92%; Horse: 80%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 88%; Rat: 100%
Target Information
CD3z complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules, and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. Diseases associated with CD3z include Immunodeficiency 25 and T-B+ Severe Combined Immunodeficiency Due To Cd3delta/Cd3epsilon/Cd3zeta.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD247 antigen; CD3 antigen, zeta polypeptide; CD3-epsilon; CD3e antigen; FLJ18683; T-cell receptor CD3 subunit zeta; T-cell receptor CD3, subunit zeta; T-cell surface glycoprotein CD3 zeta chain; T3E; TCRE
Gene Aliases: Cd3z; TCRzeta
Entrez Gene ID: (Rat) 25300
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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