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Proteintech
CD36 Polyclonal Antibody
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Product Details
18836-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Target Information
CD36, also known as scavenger receptor class B member 3, is a protein that is expressed on the surface of various cell types, including macrophages, platelets, and adipocytes. It plays a role in lipid metabolism, inflammation, and atherosclerosis, and is involved in the recognition and uptake of various ligands such as oxidized low-density lipoproteins, long-chain fatty acids, and apoptotic cells. CD36 is also implicated in the pathogenesis of malaria. The protein encoded by this gene serves as a receptor for thrombospondin in platelets and various cell lines, and is the fourth major glycoprotein of the platelet surface. It binds to collagen, thrombospondin, anionic phospholipids, and oxidized LDL, and directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. Diseases associated with CD36 include Platelet Glycoprotein IV Deficiency and Coronary Heart Disease 7.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 85 kda protein; 88 kda cell surface glycoprotein; CD36; CD36 antigen; CD36 antigen (collagen type I receptor, thrombospondin receptor); CD36 molecule (CD36 blood group) transcript; CD36 molecule (thrombospondin receptor); CD36 molecule (thrombospondin receptor) isoform CD36_1; CD36 molecule (thrombospondin receptor) isoform CD36_2; CD36 molecule (thrombospondin receptor) isoform CD36_3; cluster determinant 36; FAT; Fatty acid translocase; glycoprotein GPIIIb/GPIV; Glycoprotein IIIb; GPIIIB; GPIV; Leukocyte differentiation antigen CD36; PAS IV; PAS-4; PAS-4 protein; Platelet collagen receptor; Platelet glycoprotein 4; Platelet glycoprotein IV; scavenger receptor class B, member 3; SR-B3; Thrombospondin receptor; unnamed protein product
Gene Aliases: BDPLT10; CD36; CHDS7; FAT; GP3B; GP4; GPIV; PASIV; SCARB3
UniProt ID: (Human) P16671
Entrez Gene ID: (Human) 948
beta-amyloid binding
low-density lipoprotein receptor activity
scavenger receptor activity
long-chain fatty acid transporter activity
protein binding
high-density lipoprotein particle binding
lipid binding
short-chain fatty acid uptake transporter activity
low-density lipoprotein particle binding
Toll-like receptor binding
cargo receptor activity
macromolecular complex binding
transforming growth factor beta binding
thrombospondin receptor activity
lipoteichoic acid receptor activity
lipoprotein particle binding
oxidised low-density lipoprotein particle receptor activity
oleate transmembrane transporter activity
negative regulation of transcription from RNA polymerase II promoter
MAPK cascade
positive regulation of cell-matrix adhesion
production of molecular mediator involved in inflammatory response
lipid metabolic process
fatty acid metabolic process
lipid transport
receptor-mediated endocytosis
phagocytosis, recognition
phagocytosis, engulfment
cell adhesion
cell surface receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
blood coagulation
response to bacterium
positive regulation of gene expression
negative regulation of gene expression
positive regulation of macrophage derived foam cell differentiation
positive regulation of cholesterol storage
fatty acid transport
long-chain fatty acid transport
plasma membrane long-chain fatty acid transport
short-chain fatty acid transport
negative regulation of angiogenesis
lipid storage
cGMP-mediated signaling
positive regulation of blood coagulation
intestinal cholesterol absorption
cholesterol transport
receptor internalization
regulation of lipopolysaccharide-mediated signaling pathway
positive regulation of interleukin-1 beta production
positive regulation of interleukin-12 production
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
response to lipid
regulation of toll-like receptor signaling pathway
triglyceride transport
plasma lipoprotein particle clearance
low-density lipoprotein particle clearance
cellular response to oxidative stress
response to stilbenoid
nitric oxide-cGMP-mediated signaling pathway
negative regulation of protein import into nucleus
lipoprotein transport
positive regulation of I-kappaB kinase/NF-kappaB signaling
regulation of protein complex assembly
apoptotic cell clearance
positive regulation of MAPK cascade
long-chain fatty acid import
positive regulation of nitric oxide biosynthetic process
positive regulation of angiogenesis
defense response to Gram-positive bacterium
intestinal absorption
sensory perception of taste
low-density lipoprotein particle mediated signaling
positive regulation of phagocytosis, engulfment
positive regulation of macrophage cytokine production
positive regulation of ERK1 and ERK2 cascade
cholesterol import
response to fatty acid
response to linoleic acid
cellular response to bacterial lipopeptide
cellular response to lipopolysaccharide
cellular response to lipoteichoic acid
cellular response to low-density lipoprotein particle stimulus
cellular response to hydroperoxide
cellular response to diacyl bacterial lipopeptide
energy homeostasis
regulation of action potential
positive regulation of cold-induced thermogenesis
cellular response to oxidised low-density lipoprotein particle stimulus
oxidised low-density lipoprotein particle clearance
amyloid-beta clearance by cellular catabolic process
positive regulation of NLRP3 inflammasome complex assembly
positive regulation of protein localization to plasma membrane
positive regulation of reactive oxygen species biosynthetic process
cellular response to beta-amyloid
amyloid fibril formation
lipid transport across blood brain barrier
regulation of removal of superoxide radicals
positive regulation of blood microparticle formation
positive regulation of reactive oxygen species metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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