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|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Storage buffer||PBS with BSA, sucrose|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C, store in dark|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay-Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Flow Cytometry (Flow)||See 1 publications below|
The R-phycoerythrin (PE)-Texas Red® conjugate permits simultaneous multicolor labeling and detection of multiple targets with excitation by a single excitation source-the 488 nm line of the argon-ion laser.
CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation, proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells. Another role of CD38 is provided by enzymatic activity of its extracellular part. CD38 acts as NAD+ glycohydrolase converting NAD+ into ADP-ribose, as ADP-ribosyl cyclase producing cADPR and as cADPR hydrolase, thus affecting levels of calcium-mobilizing metabolites. ADPR produced by CD38 serves as an important second messenger of neutrophil and dendritic cell migration.
Analyte Specific Reagent
CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation.
MHCD3817 was used in flow cytometry to investigate the CSK polymorphism rs34933034 in B cells and lupus.
|Manjarrez-Orduño N,Marasco E,Chung SA,Katz MS,Kiridly JF,Simpfendorfer KR,Freudenberg J,Ballard DH,Nashi E,Hopkins TJ,Cunninghame Graham DS,Lee AT,Coenen MJ,Franke B,Swinkels DW,Graham RR,Kimberly RP,Gaffney PM,Vyse TJ,Behrens TW,Criswell LA,Diamond B,Gregersen PK||Nature genetics (44:1227)||2012|
2'-phospho-ADP-ribosyl cyclase; 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase; cADPr hydrolase 1; CD38 antigen (p45); CD38 antigen p45; cluster of differentiation 38; cyclic ADP-ribose hydrolase 1; ecto-nicotinamide adenine dinucleotide glycohydrolase; NAD(+) nucleosidase; NAD+ nucleosidase
ADPRC 1; ADPRC1; CD38