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Fabgennix
CD39 Polyclonal Antibody, FITC
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Product Details
ENTP1-FITC
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 440-490 on human EctoNucleoside TriPhosphate Diphosphohydrolase 1.
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
CD39 is an integral membrane protein characterized by two transmembrane domains and forms a homotetramer structure. It is recognized as the most prominent ectoenzyme within the immune system, primarily functioning to remove toxic extracellular ATP by converting it into ADP or AMP. CD39 works in conjunction with CD73 to hydrolyze ATP and is well characterized on Langerhans cells. Originally identified on activated lymphocytes, CD39 is expressed on a variety of immune cells, including peripheral blood B cells, monocytes, and T cell clones. It is also found on a subset of T cells, B cells, and dendritic cells, with weaker expression observed on monocytes and granulocytes. The CD39 cell surface antigen is a 70-100kD molecule, and its expression is induced on T cells and increases on B cells as a late activation antigen. CD39 possesses intrinsic ecto-ATPase activity, playing a crucial role in modulating extracellular nucleotide levels and contributing to immune regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP diphosphohydrolase; ATP-DPH; ATPDase; CD39; CD39 antigen; DKFZp686D194; DKFZp686I093; Ecto-apyrase; Ecto-ATP diphosphohydrolase 1; ecto-ATPase 1; Ecto-ATPDase 1; Ectonucleoside triphosphate diphosphohydrolase 1; FLJ40921; FLJ40959; guanosine diphosphatase homolog; Lymphoid cell activation antigen; NTPDase 1; NTPDase1; Nucleoside triphosphate diphosphohydrolase 1; unnamed protein product
Gene Aliases: 2610206B08Rik; AA408691; ATP-DPH; ATPDase; CD39; ENTPD1; NTPDase-1; SPG64
UniProt ID: (Human) P49961, (Mouse) P55772
Entrez Gene ID: (Human) 953, (Mouse) 12495, (Rat) 64519
nucleotide binding
GTPase activity
obsolete apyrase activity
guanosine-diphosphatase activity
protein binding
ATP binding
hydrolase activity
ATPase activity
nucleoside-diphosphatase activity
nucleoside-triphosphatase activity
cytidine diphosphatase activity
adenosine-diphosphatase activity
CTPase activity
uridine-diphosphatase activity
ITPase activity
IDP phosphatase activity
identical protein binding
hydrolase
nucleotide phosphatase
phosphatase
metabolite interconversion enzyme
cell adhesion
G-protein coupled receptor signaling pathway
blood coagulation
nucleoside diphosphate catabolic process
purine ribonucleoside diphosphate catabolic process
platelet activation
ADP catabolic process
platelet aggregation
metabolic process
response to proline
response to gamma radiation
response to auditory stimulus
response to caffeine
response to lipopolysaccharide
response to ATP
negative regulation of dopamine secretion
response to interferon-beta
cellular response to interferon-alpha
response to morphine
protein homooligomerization
cellular response to lipopolysaccharide
cellular response to aluminum ion
cellular response to tumor necrosis factor
response to L-arginine
negative regulation of ATP biosynthetic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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