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Proteintech
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19229-1-AP recognizes both the 3 isoforms and soluble form of CD39 (38-478 aa) molecule.
Immunogen sequence: MESEELADR VLDVVERSLS NYPFDFQGAR IITGQEEGAY GWITINYLLG KFSQKTRWFS IVPYETNNQE TFGALDLGGA STQVTFVPQN QTIESPDNAL QFRLYGKDYN VYTHSFLCYG KDQALWQKLA KDIQVASNEI LRDPCFHPGY KKVVNVSDLY KTPCTKRFEM TLPFQQFEIQ GIGNYQQCHQ SILELFNTSY CPYSQCAFNG IFLPPLQGDF GAFSAFYFVM KFLNLTSEKV SQEKVTEMMK KFCAQPWEEI KTSYAGVKEK YLSEYCFSGT YILSLLLQGY HFTADSWEHI HFIGKIQGSD AGWTLGYMLN LTNMIPAEQP LSTPLSHSTY V (1-340 aa encoded by BC047664)
CD39 is an integral membrane protein characterized by two transmembrane domains and forms a homotetramer structure. It is recognized as the most prominent ectoenzyme within the immune system, primarily functioning to remove toxic extracellular ATP by converting it into ADP or AMP. CD39 works in conjunction with CD73 to hydrolyze ATP and is well characterized on Langerhans cells. Originally identified on activated lymphocytes, CD39 is expressed on a variety of immune cells, including peripheral blood B cells, monocytes, and T cell clones. It is also found on a subset of T cells, B cells, and dendritic cells, with weaker expression observed on monocytes and granulocytes. The CD39 cell surface antigen is a 70-100kD molecule, and its expression is induced on T cells and increases on B cells as a late activation antigen. CD39 possesses intrinsic ecto-ATPase activity, playing a crucial role in modulating extracellular nucleotide levels and contributing to immune regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ATP diphosphohydrolase; ATP-DPH; ATPDase; CD39; CD39 antigen; DKFZp686D194; DKFZp686I093; Ecto-apyrase; Ecto-ATP diphosphohydrolase 1; ecto-ATPase 1; Ecto-ATPDase 1; Ectonucleoside triphosphate diphosphohydrolase 1; FLJ40921; FLJ40959; Lymphoid cell activation antigen; NTPDase 1; NTPDase1; Nucleoside triphosphate diphosphohydrolase 1
Gene Aliases: 2610206B08Rik; AA408691; ATPDase; CD39; ENTPD1; NTPDase-1; SPG64
UniProt ID: (Human) P49961, (Mouse) P55772
Entrez Gene ID: (Human) 953, (Mouse) 12495, (Rat) 64519
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