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CD39/ENTPD1 Polyclonal Antibody

CD39/ENTPD1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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CD39/ENTPD1 Antibody (19229-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human tonsillitis using 19229-1-AP (CD39 antibody) at dilution of 1:200 (under 40x lens).

CD39/ENTPD1 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

CD39/ENTPD1 Antibody in Western Blot (WB)

CD39/ENTPD1 Antibody in Flow Cytometry (Flow)

CD39/ENTPD1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

19229-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 3 publications 3 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:200

Flow Cytometry (Flow)

0.5 µg/1x10^6 cells

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CD39/ENTPD1 Fusion Protein Ag6165 (1-340 aa encoded by BC047664)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

19229-1-AP recognizes both the 3 isoforms and soluble form of CD39 (38-478 aa) molecule.

Immunogen sequence: MESEELADR VLDVVERSLS NYPFDFQGAR IITGQEEGAY GWITINYLLG KFSQKTRWFS IVPYETNNQE TFGALDLGGA STQVTFVPQN QTIESPDNAL QFRLYGKDYN VYTHSFLCYG KDQALWQKLA KDIQVASNEI LRDPCFHPGY KKVVNVSDLY KTPCTKRFEM TLPFQQFEIQ GIGNYQQCHQ SILELFNTSY CPYSQCAFNG IFLPPLQGDF GAFSAFYFVM KFLNLTSEKV SQEKVTEMMK KFCAQPWEEI KTSYAGVKEK YLSEYCFSGT YILSLLLQGY HFTADSWEHI HFIGKIQGSD AGWTLGYMLN LTNMIPAEQP LSTPLSHSTY V (1-340 aa encoded by BC047664)

Target Information

CD39 is an integral membrane protein characterized by two transmembrane domains and forms a homotetramer structure. It is recognized as the most prominent ectoenzyme within the immune system, primarily functioning to remove toxic extracellular ATP by converting it into ADP or AMP. CD39 works in conjunction with CD73 to hydrolyze ATP and is well characterized on Langerhans cells. Originally identified on activated lymphocytes, CD39 is expressed on a variety of immune cells, including peripheral blood B cells, monocytes, and T cell clones. It is also found on a subset of T cells, B cells, and dendritic cells, with weaker expression observed on monocytes and granulocytes. The CD39 cell surface antigen is a 70-100kD molecule, and its expression is induced on T cells and increases on B cells as a late activation antigen. CD39 possesses intrinsic ecto-ATPase activity, playing a crucial role in modulating extracellular nucleotide levels and contributing to immune regulation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

STAT3 promotes differentiation of monocytes to MDSCs via CD39/CD73-adenosine signal pathway in oral squamous cell carcinoma.

Cancer immunology, immunotherapy : CII

Cui H,Lan Z,Zou KL,Zhao YY,Yu GT

Mon May 01 00:00:00 UTC 2023

STAT3 promotes differentiation of monocytes to MDSCs via CD39/CD73-adenosine signal pathway in oral squamous cell carcinoma.

Cancer immunology, immunotherapy : CII

Cui H,Lan Z,Zou KL,Zhao YY,Yu GT

Mon May 01 00:00:00 UTC 2023

Identification of Novel CD39 Inhibitors Based on Virtual Screening and Enzymatic Assays.

Journal of chemical information and modeling

Zhao Y,Chen X,Ding Z,He C,Gao G,Lyu S,Gao Y,Du J

Mon Nov 14 00:00:00 UTC 2022

Epithelial miR-206 targets CD39/extracellular ATP to upregulate airway IL-25 and TSLP in type 2-high asthma.

JCI insight

Zhang K,Feng Y,Liang Y,Wu W,Chang C,Chen D,Chen S,Gao J,Chen G,Yi L,Cheng D,Zhen G

Tue Jun 08 00:00:00 UTC 2021

Characterization of soluble CD39 (SolCD39/NTPDase1) from PiggyBac nonviral system as a tool to control the nucleotides level.

The Biochemical journal

Beckenkamp LR,Iser IC,Onzi GR,Fontoura DMSD,Bertoni APS,Sévigny J,Lenz G,Wink MR

Tue Jun 11 00:00:00 UTC 2019

Alpl prevents bone ageing sensitivity by specifically regulating senescence and differentiation in mesenchymal stem cells.

Bone research

Liu W,Zhang L,Xuan K,Hu C,Liu S,Liao L,Li B,Jin F,Shi S,Jin Y

Wed Jul 28 00:00:00 UTC 2021

Alpl prevents bone ageing sensitivity by specifically regulating senescence and differentiation in mesenchymal stem cells.

Bone research

Liu W,Zhang L,Xuan K,Hu C,Liu S,Liao L,Li B,Jin F,Shi S,Jin Y

Wed Jul 28 00:00:00 UTC 2021

Bioinformatics

Protein Aliases: ATP diphosphohydrolase; ATP-DPH; ATPDase; CD39; CD39 antigen; DKFZp686D194; DKFZp686I093; Ecto-apyrase; Ecto-ATP diphosphohydrolase 1; ecto-ATPase 1; Ecto-ATPDase 1; Ectonucleoside triphosphate diphosphohydrolase 1; FLJ40921; FLJ40959; Lymphoid cell activation antigen; NTPDase 1; NTPDase1; Nucleoside triphosphate diphosphohydrolase 1

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Gene Aliases: 2610206B08Rik; AA408691; ATPDase; CD39; ENTPD1; NTPDase-1; SPG64

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UniProt ID: (Human) P49961, (Mouse) P55772

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Entrez Gene ID: (Human) 953, (Mouse) 12495, (Rat) 64519

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Function(s)

protein binding ATP binding hydrolase activity ATPase activity nucleoside-diphosphatase activity nucleoside-triphosphatase activity identical protein binding adenosine-diphosphatase activity hydrolase nucleotide phosphatase phosphatase metabolite interconversion enzyme

Process(es)

cell adhesion blood coagulation G-protein coupled receptor signaling pathway metabolic process purine ribonucleoside diphosphate catabolic process response to proline response to gamma radiation response to auditory stimulus platelet activation response to caffeine response to lipopolysaccharide response to ATP negative regulation of dopamine secretion response to interferon-beta cellular response to interferon-alpha response to morphine protein homooligomerization cellular response to lipopolysaccharide cellular response to aluminum ion cellular response to tumor necrosis factor response to L-arginine negative regulation of ATP biosynthetic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CD39/ENTPD1 Polyclonal Antibody

CD39/ENTPD1 Antibody (19229-1-AP) in IHC (P)

Product Details

19229-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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