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Invitrogen

CD3e/CD3g Recombinant Rabbit Monoclonal Antibody (4F5G4)

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CD3e/CD3g Recombinant Rabbit Monoclonal Antibody (4F5G4)

Product Details

MA5-42744

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:5,000
-

Flow Cytometry (Flow)

1:500-1:1,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

4F5G4

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-207(CD3E)& 1-182(CD3G) of human CD3 epsilon&CD3 gamma Heterodimer
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.0 mg/mL

Amount

100 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.09% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2911885

Product Specific Information

The target is usually found in the following locations: Cell membrane, Single-pass type I membrane protein, Membrane, Single-pass type I membrane protein.

Immunogen sequence: MQSGTHWRVL GLCLLSVGVW GQDGNEEMGG ITQTPYKVSI SGTTVILTCP QYPGSEILWQ HNDKNIGGDE DDKNIGSDED HLSLKEFSEL EQSGYYVCYP RGSKPEDANF YLYLRARVCE NCMEMDVMSV ATIVIVDICI TGGLLLLVYY WSKNRKAKAK PVTRGAGAGG RQRGQNKERP PPVPNPDYEP IRKGQRDLYS GLNQRRI(CD 3E)&MEQGKG LAVLILAIIL LQGTLAQSIK GNHLVKVYDY QEDGSVLLTC DAEAKNITWF KDGKMIGFLT EDKKKWNLGS NAKDPRGMYQ CKGSQNKSKP LQVYYRMCQN CIELNAATIS GFLFAEIVSI FVLAVGVYFI AGQDGVRQSR ASDKQTLLPN DQLYQPLKDR EDDQYSHLQG NQLRRN(CD3 G)

Target Information

The CD3 subunit complex which is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. The genes encoding the CD3 epsilon, gamma and delta polypeptides are located on chromosome 11. Defects in the CD3 gene are associated with CD3 immunodeficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD3-epsilon; CD3e; CD3e antigen, epsilon polypeptide (TiT3 complex); CD3e molecule, epsilon (CD3-TCR complex); CD3g; CD3g antigen, gamma polypeptide (TiT3 complex); CD3g molecule, epsilon (CD3-TCR complex); CD3g molecule, gamma (CD3-TCR complex); T-cell antigen receptor complex, epsilon subunit of T3; T-cell antigen receptor complex, gamma subunit of T3; T-cell receptor T3 gamma chain; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 epsilon chain; T-cell surface glycoprotein CD3 gamma chain; unnamed protein product

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Gene Aliases: CD3-GAMMA; CD3E; CD3epsilon; CD3G; CD3GAMMA; IMD17; IMD18; T3E; T3G; TCRE

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UniProt ID: (Human) P07766, (Human) P09693

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Entrez Gene ID: (Human) 916, (Human) 917

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Function(s)
transmembrane signaling receptor activity protein binding SH3 domain binding protein kinase binding receptor signaling complex scaffold activity T cell receptor binding identical protein binding
Process(es)
adaptive immune response immune system process establishment or maintenance of cell polarity cell surface receptor signaling pathway protein transport T cell activation positive thymic T cell selection gamma-delta T cell activation alpha-beta T cell activation T cell receptor signaling pathway protein-containing complex assembly regulation of lymphocyte apoptotic process positive regulation of cell-matrix adhesion positive regulation of T cell anergy T cell anergy transmembrane receptor protein tyrosine kinase signaling pathway signal complex assembly G-protein coupled receptor signaling pathway smoothened signaling pathway regulation of signal transduction positive regulation of gene expression negative regulation of gene expression dendrite development calcium-mediated signaling cerebellum development T cell costimulation positive regulation of interferon-gamma production positive regulation of interleukin-2 production positive regulation of interleukin-4 production positive regulation of cell-cell adhesion mediated by integrin CD4-positive, alpha-beta T cell proliferation T cell proliferation positive regulation of T cell proliferation regulation of apoptotic process positive regulation of MAPK cascade negative thymic T cell selection negative regulation of smoothened signaling pathway lymphocyte activation positive regulation of calcium-mediated signaling positive regulation of T cell activation apoptotic signaling pathway positive regulation of CD4-positive, alpha-beta T cell proliferation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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