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CD4/CD26 Antibody Cocktail, FITC, PE
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Product Details
0426S
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, IgG2a
Class
Cocktail
Type
Antibody
Immunogen
CD4 was derived from the hybridization of mouse NS-1 myeloma cells with spleen cells from BALB/c mice immunized with human perherial blood T lymphocytes.
Conjugate
Form
Liquid
Purification
Protein A/G
Storage buffer
PBS with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Flow Cytometry PBMC: Add 10 µL of MAB/10^6 PBMC in 100 µL PBS. Mix gently and incubate for 15 minutes at 2 to 8C. Wash twice with PBS and analyze or fix with 0.5% v/v of paraformaldehyde in PBS and analyze.
Flow Cytometry Whole Blood: Add10 µL of MAB/100 µL of whole blood. Mix gently and incubate for 15 minutes at room temperature 20C. Lyse the whole blood. Wash once with PBS and analyze or fix with 0.5% v/v of paraformaldehyde in PBS and analyze. See instrument manufacturer instructions for Lysed Whole Blood and Immunofluorescence analysis with a flow cytometer or microscope.
Target Information
The CD4 antigen is involved in the recognition of the type II MHC antigen. It is also a receptor for HIV. It is present on most T helper cells and normal thymocytes. The cytoplasmic portion of CD4 is associated with p56lck tyrosine kinase. CD4 expression is commonly found in human lymph nodes and tonsils. CD26 [also known as dipeptidyl peptidase IV (DPP IV), adenosine deaminase (ADA) binding protein]. 1 - 3 is an atypical serine protease belonging to the prolyl oligopeptidase family. It is expressed on lymphocyte cells and is upregulated during T-cell activation. CD26 is also expressed on activated B cells and natural killer cells and abundantly on epithelia. CD26 is implicated in a variety of biological functions including T-cell activation, cell adhesion with extracellular matrix such as fibronectin or collagens, and in HIV infection. Cross-linking of CD26 using this antibody dramatically enhances the anti CD3-induced IL - 2 production.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ADABP; ADCP-2; Adenosine deaminase complexing protein 2; CD26; CD4; CD4 antigen (p55); CD4 antigen p55; CD4 receptor; Dipeptidyl peptidase 4; Dipeptidyl peptidase IV; dipeptidyl-peptidase 4; dipeptidylpeptidase 4; dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2); DPP IV; DPP-IV; T-cell activation antigen CD26; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4; TP103
Gene Aliases: ADABP; ADCP2; CD26; CD4; CD4mut; DPP4; DPPIV; TP103
UniProt ID: (Human) P01730, (Human) P27487
Entrez Gene ID: (Human) 920, (Human) 1803
virus receptor activity
glycoprotein binding
receptor activity
transmembrane signaling receptor activity
extracellular matrix structural constituent
protein binding
zinc ion binding
coreceptor activity
immunoglobulin binding
enzyme binding
protein kinase binding
MHC class II protein binding
protein homodimerization activity
protein tyrosine kinase binding
protease binding
serine-type endopeptidase activity
receptor binding
serine-type peptidase activity
dipeptidyl-peptidase activity
identical protein binding
serine protease
cytokine production
adaptive immune response
induction by virus of host cell-cell fusion
immune response
signal transduction
cell surface receptor signaling pathway
enzyme linked receptor protein signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of calcium ion transport into cytosol
fusion of virus membrane with host plasma membrane
T cell differentiation
entry into host cell
T cell costimulation
response to estradiol
maintenance of protein location in cell
response to vitamin D
helper T cell enhancement of adaptive immune response
positive regulation of T cell proliferation
T cell selection
positive regulation of interleukin-2 biosynthetic process
positive regulation of protein kinase activity
regulation of defense response to virus by virus
positive regulation of peptidyl-tyrosine phosphorylation
defense response to Gram-negative bacterium
positive regulation of calcium-mediated signaling
T cell receptor signaling pathway
regulation of T cell activation
behavioral fear response
response to hypoxia
proteolysis
positive regulation of cell proliferation
negative regulation of extracellular matrix disassembly
regulation of cell-cell adhesion mediated by integrin
locomotory exploration behavior
psychomotor behavior
T cell activation
endothelial cell migration
viral entry into host cell
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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