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Proteintech
CD42b Polyclonal Antibody
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Product Details
12860-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CD42b Fusion Protein Ag3893 (19-350 aa encoded by BC027955)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: ICEVSKVAS HLEVNCDKRN LTALPPDLPK DTTILHLSEN LLYTFSLATL MPYTRLTQLN LDRCELTKLQ VDGTLPVLGT LDLSHNQLQS LPLLGQTLPA LTVLDVSFNR LTSLPLGALR GLGELQELYL KGNELKTLPP GLLTPTPKLE KLSLANNNLT ELPAGLLNGL ENLDTLLLQE NSLYTIPKGF FGSHLLPFAF LHGNPWLCNC EILYFRRWLQ DNAENVYVWK QGVDVKAMTS NVASVQCDNS DKFPVYKYPG KGCPTLGDEG DTDLYDYYPE EDTEGDKVRA TRTVVKFPTK AHTTPWGLFY SWSTASLDSQ MPSSLHPTQE STK (19-350 aa encoded by BC027955)
Target Information
CD42b is a platelet activation marker involved in the process of coagulation as an aggregating factor. It interacts with extracellular matrix as well as with adhesion molecules. CD42b expression and activation seems to be regulated by VEGF and PDGF. CD42b composes together with GPIb beta, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis. Further, CD42b antigen is expressed on platelets and on megakaryocytes in bone marrow. Several polymorphisms and mutations have been described in the CD42b, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Antigen CD42b-alpha; CD42a; CD42b; glycoprotein Ib (platelet), alpha polypeptide; glycoprotein Ib platelet alpha subunit; glycoprotein Ibalpha; GP-Ib alpha; GP-IX; GPIB; GPIb alpha; GPIX; MGC34595; mutant platelet membrane glycoprotein Ib-alpha; Platelet glycoprotein Ib alpha chain; platelet glycoprotein Ib alpha polypeptide; Platelet GPIX; platelet membrane glycoprotein 1b-alpha subunit; platelet membrane glycoprotein Ib-alpha
Gene Aliases: BDPLT1; BDPLT3; BSS; CD42B; CD42b-alpha; DBPLT3; GP1B; GP1BA; GPIBA; GPIbalpha; VWDP
UniProt ID: (Human) P07359, (Mouse) O35930
Entrez Gene ID: (Human) 2811, (Pig) 100515052, (Mouse) 14723
cell morphogenesis
negative regulation of protein kinase activity
cell adhesion
cell surface receptor signaling pathway
blood coagulation
blood coagulation, intrinsic pathway
cytokine-mediated signaling pathway
platelet activation
regulation of blood coagulation
fibrinolysis
negative regulation of JAK-STAT cascade
thrombin receptor signaling pathway
hemostasis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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