Immunogen sequence: PPTFEAMEL IGKPKPYYEI GERVDYKCKK GYFYIPPLAT HTICDRNHTW LPVSDDACYR ETCPYIRDPL NGQAVPANGT YEFGYQMHFI CNEGYYLIGE EILYCELKGS VAIWSGKPPI CEKVLCTPPP KIKNGKHTFS EVEVFEYLDA VTYSCDPAPG PDPFSLIGES TIYCGDNSVW SRAAPECKVV KCRFPVVENG KQISGFGKKF YYKATVMFEC DKGFYLDGSD TIVCDSNSTW DPPVPKCLKV STSSTTKSPA SSASGPRPTY KPPVSNYPGY PKPEEGILDS LDVWVIAVIV IAIV (38-340 aa encoded by BC030594)
CD46 (MCP, membrane cofactor protein) is a multifunctional cell surface transmembrane protein that binds and inactivates C3b and C4b complement fragments, regulates T cell-induced inflammatory responses by either inhibiting (CD46-1 isoform) or increasing (CD46-2 isoform) the contact hypersensitivity reaction. CD46 also serves as a receptor for several human pathogens (both bacteria and viruses), and its ligation alteres T lymphocyte polarization toward antigen-presenting cells or target cells, inhibiting lymphocyte function. CD46 is a protector of placental tissue and is also expressed on the inner acrosomal membrane of spermatozoa.
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Protein Aliases: antigen identified by monoclonal antibody TRA-2-10; CD46; CD46 antigen, complement regulatory protein; CD46 molecule, complement regulatory protein; complement membrane cofactor protein; measles virus receptor; Membrane cofactor protein; membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen); MGC26544; TLX; trophoblast leucocyte common antigen; Trophoblast leukocyte common antigen; trophoblast-lymphocyte cross-reactive antigen
Gene Aliases: AHUS2; CD46; MCP; MIC10; TLX; TRA2.10