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Invitrogen
CD49a (Integrin alpha 1) Polyclonal Antibody
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FIGURE: 1 / 1
CD49a (Integrin alpha 1) Antibody (PA5-143201) in WB
Western Blot analysis of CD49a (Integrin alpha 1) in HeLa (A) and HepG2 (B) lysates (35 µg protein in RIPA buffer) using CD49a (Integrin alpha 1) Polyclonal Antibody (Product # PA5-143201) at 0.5 µg/mL incubated for 1 hour. Detected by chemiluminescence.
Product Details
PA5-143201
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence C-DKHDFQDSVRIT.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Target Information
Integrin alpha 1 (ITGA1) chain associates with the beta 1 (ITGB1) chain to form a heterodimer that functions as a dual laminin/collagen receptor in neural cells and hematopoietic cells. ITGA1 has a 206-amino acid I domain in its N-terminal half, followed by 3 divalent cation-binding sites and a C-terminal transmembrane domain with a short cytoplasmic tail. It also has 28 potential N-glycosylation sites. Human ITGA1 was expressed in a mouse fibroblast cell line as a 180-kD protein. ITGA1 is involved in the early remodeling of osteoarthritic cartilage and plays an essential role in the regulation of mesenchymal stem cell proliferation and cartilage production. It also plays an essential role in the regulation of MSC proliferation and cartilage production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD49 antigen-like family member A; CD49a; Integrin alpha-1; Laminin and collagen receptor; unnamed protein product; very late activation protein 1; very late antigen-1; VLA-1
Gene Aliases: CD49a; ITGA1; VLA1
UniProt ID: (Human) P56199
Entrez Gene ID: (Human) 3672
cell adhesion
cell-matrix adhesion
integrin-mediated signaling pathway
negative regulation of cell proliferation
neutrophil chemotaxis
negative regulation of epidermal growth factor receptor signaling pathway
vasodilation
positive regulation of MAPK cascade
positive regulation of neuron apoptotic process
cellular extravasation
neuron projection morphogenesis
cell chemotaxis
cell-cell adhesion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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