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Invitrogen
CD49c (Integrin alpha 3) Polyclonal Antibody
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FIGURE: 1 / 7
CD49c (Integrin alpha 3) Antibody (PA5-79528) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis of CD49c (Integrin alpha 3) in A431 cells using CD49c (Integrin alpha 3) Polyclonal Antibody (Product # PA5-79528). Enzyme antigen retrieval was performed using IHC enzyme antigen retrieval reagent for 15 mins. The cells were blocked with 10% goat serum and incubated with the primary antibody at 5 µg/mL. DyLight 488 conjugated goat anti-rabbit IgG was used as ... View More
Product Details
PA5-79528
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human Integrin alpha 3 (51-67aa LFGYSVALHRQTERQQR).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg thimerosal, 0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human U87 whole cell, human A431 whole cell, human A549 whole cell, human U2OS whole cell, rat C6 whole cell, rat PC-12 whole cell. IHC: human lung cancer tissue, human colorectal adenocarcinoma tissue. ICC/IF: A431 cell. Flow: U87 cell.
Target Information
ITGA3 (INTEGRIN, ALPHA-3), also called CD49C, VLA3 or GAPB3, is a protein that in humans is encoded by the ITGA3 gene. ITGA3 is an integrin alpha subunit which is also a member of the family of cell surface adhesion molecules. ITGA3 is mapped to chromosome 17 and its exact cytogenetic location is 17q21.33. ITGA3 makes up half of the alpha3beta1 integrin duplex that plays a role in neural migration and corticogenesis together with beta-1 subunit. A functional link between DAB1 phosphorylation and ITGA3 signaling drives the timely detachment of migrating neurons from radial glial fibers. Expression of human ITGA3 increased the infectivity of virus for Chinese hamster ovary cells. ITGA3 also contains 13 potential N-glycosylation sites, 2 potential cleavage sites, and the 7 N-terminal repeating units characteristic of ITGAs. Recombinant ITGA3 is expressed as a 150-kD protein as the same size as the native protein by the western blot analysis.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha 3 subunit of VLA-3 receptor; Alpha3 integrin; antigen CD49C; antigen identified by monoclonal antibody J143; CD49 antigen-like family member C; CD49c; CD49c antigen; FLJ34631; FLJ34704; FRP-2; Galactoprotein B3; GAPB3; integrin alpha 3; Integrin alpha-3; Integrin alpha3; integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor); testicular tissue protein Li 96; testicular tissue protein Li 98; unnamed protein product; very late activation protein 3 receptor, alpha-3 subunit; very late activation receptor subunit alpha-3; VLA-3 subunit alpha
Gene Aliases: CD49C; FRP-2; GAP-B3; GAPB3; ILNEB; ITGA3; JEB7; MSK18; VCA-2; VL3A; VLA3a
UniProt ID: (Human) P26006
Entrez Gene ID: (Human) 3675, (Rat) 360606
neuron migration
system process
cell adhesion
cell-matrix adhesion
integrin-mediated signaling pathway
Rho protein signal transduction
heart development
memory
response to xenobiotic stimulus
regulation of signal transduction
positive regulation of gene expression
positive regulation of epithelial cell migration
positive regulation of cell-substrate adhesion
positive regulation of neuron projection development
regulation of transforming growth factor beta receptor signaling pathway
regulation of Wnt signaling pathway
cell differentiation
lung development
regulation of BMP signaling pathway
negative regulation of cell projection organization
response to gonadotropin
negative regulation of Rho protein signal transduction
exploration behavior
skin development
mesodermal cell differentiation
system development
leukocyte migration
maternal process involved in female pregnancy
nephron development
dendritic spine maintenance
renal filtration
cell-cell adhesion
postsynapse organization
synaptic membrane adhesion
positive regulation of protein localization to plasma membrane
fusion of sperm to egg plasma membrane
response to drug
single-organism behavior
positive regulation of establishment of protein localization to plasma membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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