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Invitrogen
CD49d (Integrin alpha 4) Polyclonal Antibody
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FIGURE: 1 / 1
CD49d (Integrin alpha 4) Antibody (PA5-87487) in WB
Western blot analysis of CD49d (Integrin alpha 4) in Jurkat cells. Samples were incubated with CD49d (Integrin alpha 4) Polyclonal antibody (Product # PA5-87487) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.
Product Details
PA5-87487
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein (or fragment)
Conjugate
Form
Liquid
Concentration
6.05 mg/mL
Amount
605 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LKYEVKLTVH GFVNPTSFVY GSNDENEPET CMVEKMNLTF HVINTGNSMA PNVSVEIMVP NSFSPQTDKL FNILDVQTTT GECHFENYQR VCALEQQKSA MQTLKGIVRF LSKTDKRLLY CIKADPHCLN FLCNFGKMES GKEASVHIQL EGRPSILEMD ETSALKFEIR ATGFPEPNPR VIELNKDENV AHVLLEGLHH Q
Positive Samples: Jurkat; Cellular Location: Membrane, Single-pass type I membrane protein
Target Information
The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chains. Alpha4 chain associates with either beta1 or beta7 chain. It has been demonstrated that the putative ligand-binding sites of both integrin alpha4beta1 and alpha4beta7 is located on the alpha4 chain. These ligands included Madcam, VCAM, and fibronectin. Madcam is known as the principal ligand for integrin alpha4beta7. Recently it was also demonstrated that HIV-1 envelope can mimic Madcam by binding to and signaling though integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 269C wild type; alpha 4 subunit of VLA-4 receptor; antigen CD49D, alpha-4 subunit of VLA-4 receptor; CD49 antigen-like family member D; CD49d; Integrin alpha-4; Integrin alpha-IV; ITGA-IV; unnamed protein product; very late activation protein 4 receptor, alpha 4 subunit; VLA-4 subunit alpha
Gene Aliases: CD49D; IA4; ITGA4
UniProt ID: (Human) P13612
Entrez Gene ID: (Human) 3676
immune response in gut-associated lymphoid tissue
positive regulation of leukocyte migration
cell-matrix adhesion involved in ameboidal cell migration
cell adhesion
leukocyte cell-cell adhesion
cell-matrix adhesion
integrin-mediated signaling pathway
tissue development
B cell differentiation
cell-cell adhesion mediated by integrin
heterotypic cell-cell adhesion
substrate adhesion-dependent cell spreading
endodermal cell differentiation
receptor clustering
negative regulation of vasoconstriction
embryonic morphogenesis
leukocyte migration
leukocyte tethering or rolling
diapedesis
axonogenesis involved in innervation
cellular response to cytokine stimulus
negative regulation of protein homodimerization activity
cell-cell adhesion
import into cell
positive regulation of leukocyte cell-cell adhesion
positive regulation of leukocyte tethering or rolling
cellular response to beta-amyloid
positive regulation of vascular endothelial cell proliferation
neuron projection extension
clathrin-mediated extracellular exosome endocytosis
positive regulation of endothelial cell apoptotic process
positive regulation of T cell migration
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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