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Invitrogen
CD51 Polyclonal Antibody
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Product Details
PA5-97882
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Integrin alpha-V protein (775-885AA)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8, 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands, the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: antigen identified by monoclonal antibody L230; CD51; Integrin alpha-V; integrin alphaVbeta3; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); unnamed protein product; vitronectin alpha subunit precursor; Vitronectin receptor; Vitronectin receptor subunit alpha
Gene Aliases: CD51; ITGAV; MSK8; VNRA; VTNR
UniProt ID: (Human) P06756
Entrez Gene ID: (Human) 3685
virus receptor activity
opsonin binding
fibronectin binding
protease binding
protein kinase C binding
receptor binding
integrin binding
protein binding
coreceptor activity
fibroblast growth factor binding
C-X3-C chemokine binding
insulin-like growth factor I binding
signaling receptor activity
neuregulin binding
metal ion binding
transforming growth factor beta binding
extracellular matrix binding
extracellular matrix protein binding
angiogenesis
blood vessel development
vasculogenesis
formation of primary germ layer
cell adhesion
cell-matrix adhesion
positive regulation of cytosolic calcium ion concentration
integrin-mediated signaling pathway
positive regulation of cell proliferation
tissue development
negative regulation of macrophage derived foam cell differentiation
negative regulation of lipid storage
negative regulation of low-density lipoprotein particle clearance
cell migration
positive regulation of cell migration
cell-substrate adhesion
negative regulation of lipid transport
cell adhesion mediated by integrin
positive regulation of osteoblast proliferation
heterotypic cell-cell adhesion
substrate adhesion-dependent cell spreading
wound healing, spreading of epidermal cells
endodermal cell differentiation
apolipoprotein A-I-mediated signaling pathway
apoptotic cell clearance
positive regulation of cell adhesion
viral entry into host cell
negative regulation of lipoprotein metabolic process
regulation of phagocytosis
negative chemotaxis
positive regulation of small GTPase mediated signal transduction
ERK1 and ERK2 cascade
calcium ion transmembrane transport
transforming growth factor beta production
entry into host cell by a symbiont-containing vacuole
extrinsic apoptotic signaling pathway in absence of ligand
cell-cell adhesion
positive regulation of intracellular signal transduction
negative regulation of entry of bacterium into host cell
negative regulation of extrinsic apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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