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Product Details
PA5-103301
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:1,000-1:3,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:200 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Non-human primate |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
A synthesized peptide derived from human CD52(Accession P31358), corresponding to amino acid residues Q18-S39. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1 mg/mL |
Purification |
Affinity chromatography |
Storage buffer |
PBS, pH 7.4, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
RRID |
AB_2852648 |
Target Information
Human CD52, also known as Cambridge pathology antigen 1 (CAMPATH-1), is a glycoprotein found in the male reproductive tract and immune cells. It is abundantly expressed on the surface of nearly all human peripheral blood lymphocytes. The CD52 antigen is GPI-anchored membrane receptor that consists of a small 12 amino acid peptide attached to a large N-linked carbohydrate group. CD52 is a potent target for inducing cytolysis of mature lymphocytes. Alemtuzumab, a humanized monoclonal antibody targeting CD52, is used as an immunomodulatory drug for the treatment of chronic lymphocytic leukemia, T cell lymphomas, multiple sclerosis, and other diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cambridge pathology 1 antigen; CAMPATH-1 antigen; CD52; CD52 antigen; CD52 antigen (CAMPATH-1 antigen); CDw52; CDW52 antigen (CAMPATH-1 antigen); Epididymal secretory protein E5; epididymis secretory sperm binding protein Li 171mP; He5; HEL-S-171mP; Human epididymis-specific protein 5
Gene Aliases: CD52; CDW52; HE5
UniProt ID: (Human) P31358
Entrez Gene ID: (Human) 1043
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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