Immunogen sequence: AILLFVYEQK LNEYVAKGLT DSIHRYHSDN STKAAWDSIQ SFLQCCGING TSDWTSGPPA SCPSDRKVEG CYAKARLWFH S; Positive Samples: B cells, Jurkat, Raji, HL-60, Mouse liver, Mouse spleen, Mouse lung; Cellular Location: Cell junction, Cell membrane, Membrane, Multi-pass membrane protein
CD53 is a tetraspanin family transmembrane glycoprotein expressed in the lymphoid-myeloid lineage. This molecule has been reported to form complexes with other leukocyte surface proteins such as CD2, CD19, CD21, MHC II, VLA-4 or tetraspanins CD37, CD81 and CD82, thus probably modulating various signaling processes. CD53 is involved in radioresistancy of tumor cells and its triggering has anti-apoptotic effect. In thymus, CD53 is up-regulated in response to positive selection signals during T cell development, and is strongly expressed upon macrophage exposure to bacterial lipopolysaccharide, whereas stimulation of neutrophils results in down-regulation of CD53 expression.
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Protein Aliases: antigen MOX44 identified by monoclonal antibody MRC-OX44; CD53; CD53 antigen; CD53 glycoprotein; CD53 tetraspan antigen; cell surface antigen; Cell surface glycoprotein CD53; Leukocyte surface antigen CD53; Tetraspanin-25; transmembrane glycoprotein; Tspan-25
Gene Aliases: AI323659; CD53; MOX44; Ox-44; TSPAN25