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      View (19) other CD73 antibodies

      Invitrogen

      CD73 Monoclonal Antibody (7G2)

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      Catalog #:41-0200

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      Product Details

      TESTED APPLICATIONS DILUTION
      Flow Cytometry (Flow) Assay Dependent
      Functional Assay (FN) Assay Dependent
      Inhibition Assays (IA) Assay Dependent
      Immunohistochemistry (Frozen) (IHC (F)) Assay Dependent
      Immunoprecipitation (IP) Assay Dependent
      PUBLISHED APPLICATIONS
      Immunohistochemistry (IHC) See 2 publications below
      Immunofluorescence (IF) See 1 publications below
      Flow Cytometry (Flow) See 1 publications below
      Immunoprecipitation (IP) See 1 publications below
      Tested Species reactivity Human
      Published species reactivity Human
      Host / Isotype Mouse / IgG2a, kappa
      Class Monoclonal
      Type Antibody
      Clone 7G2
      Immunogen Highly purified human placental CD73 protein
      Conjugate Unconjugated
      Form Liquid
      Concentration 0.5 mg/ml
      Purification Affinity chromatography
      Storage buffer PBS, pH 7.4
      Contains 0.1% sodium azide
      Storage conditions -20°C
      RRID AB_2533492

      Background/Target Information

      Ecto-5-prime-nucleotidase (5-prime-ribonucleotide phosphohydrolase) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. The enzyme consists of a dimer of 2 identical 70 kD subunits bound externally to the plasma membrane by a glycosyl phosphatidyl inositol linkage. The enzyme is used as a marker of lymphocyte differentiation. Consequently, a deficiency of NT5E occurs in a variety of immunodeficiency diseases. Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from ecto-NT5 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate. It is not known whether the different enzymes are coded by different genes or result from different posttranslational modifications of a single coding sequence.

      For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

      References (5)

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      Bioinformatics

      Protein Aliases: 5'-NT; 5'-nucleotidase; 5'-nucleotidase, ecto (CD73); CD73; E5NT; Ecto-5'-nucleotidase; eN; eNT; NT; NT5; NTE; Purine 5-Prime-Nucleotidase

      Gene Aliases: CALJA; CD73; E5NT; eN; eNT; NT; NT5; NT5E; NTE

      UniProt ID: (Human) P21589

      Entrez Gene ID: (Human) 4907

      Molecular Function: phosphodiesterase

      Suggested Secondary Antibodies

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      Material safety data sheets (MSDS)

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