|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated synthetic peptide between 150-180 amino acids from the C-terminal region of human CD8A|
|Purification||Antigen affinity chromatography|
|Contains||0.09% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1:10-1:50|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (IHC)||See 1 publications below|
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a co-receptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional co-receptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
CD161(high)CD8+T cells bear pathogenetic potential in multiple sclerosis.
PA5-11454 was used in immunohistochemistry to investigate the pathogenetic potential of CD161(high)CD8+ T cells in multiple sclerosis
|Annibali V,Ristori G,Angelini DF,Serafini B,Mechelli R,Cannoni S,Romano S,Paolillo A,Abderrahim H,Diamantini A,Borsellino G,Aloisi F,Battistini L,Salvetti M||Brain : a journal of neurology (134:542)||2011|