|Flow Cytometry (Flow)||Assay Dependent|
|Miscellaneous PubMed (MISC)||See 1 publications below|
|Immunofluorescence (IF)||See 1 publications below|
|Immunohistochemistry (Paraffin) (IHC (P))||See 1 publications below|
|Host / Isotype||Rat / IgG2b|
|Immunogen||Con A-stimulated BALB/c splenic T cells|
Alexa Fluor® 488
|Excitation/Emission Profile||View spectra|
|Storage buffer||PBS with BSA|
|Contains||0.1% sodium azide|
|Storage conditions||4° C|
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a corepressor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains, or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain isoforms. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CD8; CD8a; Leu-2; Lyt-2.1 lymphocyte differentiation antigen (AA at 100); MAL; T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein Lyt-2
Gene Aliases: BB154331; Cd8a; Ly-2; Ly-35; Ly-B; Lyt-2; Lyt2
UniProt ID: (Mouse) P01731
Entrez Gene ID: (Mouse) 12525
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.