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Invitrogen
CD89 Monoclonal Antibody (MIP8a), PE
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Product Details
MA5-28107
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
MIP8a
Immunogen
Recombinant soluble human Fc alpha R
Conjugate
Excitation/Emission Max
565/576 nm
View spectra
Form
Lyophilized
Concentration
Conc. not determined
Purification
purified
Storage buffer
PBS with 1% BSA, 5% sucrose
Contains
0.09% sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody recognizes the human CD89 cell surface antigen, a 50-75 kDa cell surface glycoprotein that is also known as the IgA receptor (Fc alpha R). CD89 is expressed by peripheral blood monocytes and neutrophils. MIP8a blocks binding of IgA to the Fc alpha R, and also inhibits neutrophil phagocytosis of IgA complexes.
Reconstitute with 1 mL distilled water.
Target Information
This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD89; Fc fragment of IgA receptor; Fc fragment of IgA, receptor for; IgA Fc receptor; IgA Fc receptor Fc alpha Rla2 variant; Immunoglobulin alpha Fc receptor; unnamed protein product
Gene Aliases: CD89; CTB-61M7.2; FcalphaR; FcalphaRI; FCAR
UniProt ID: (Human) P24071
Entrez Gene ID: (Human) 2204
neutrophil mediated immunity
immune response-regulating signaling pathway
immune response
positive regulation of neutrophil apoptotic process
cellular response to interferon-alpha
Fc receptor signaling pathway
neutrophil activation
cellular response to lipopolysaccharide
cellular response to interferon-gamma
cellular response to interleukin-6
cellular response to tumor necrosis factor
cellular response to granulocyte macrophage colony-stimulating factor stimulus
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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