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Invitrogen

CD91 Polyclonal Antibody

View all (60) LRP1 (CD91) antibodies

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CD91 Polyclonal Antibody

Product Details

PA5-89273

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 20-168 of LRP1 (NP_0023232)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.13 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2805459

Product Specific Information

Immunogen sequence: AIDAPKTCSP KQFACRDQIT CISKGWRCDG ERDCPDGSDE APEICPQSKA QRCQPNEHNC LGTELCVPMS RLCNGVQDCM DGSDEGPHCR ELQGNCSRLG CQHHCVPTLD GPTCYCNSSF QLQADGKTCK DFDECSVYGT CSQLCTNTD

Positive Samples: Cellular Location: Cell membrane, Cytoplasm, Extracellular side, Membrane, Nucleus, Peripheral membrane protein, Single-pass type I membrane protein, coated pit

Target Information

CD91 is a 600 kDa type I transmembrane protein composed of an alpha and beta chain. The alpha chain interacts with a variety of structurally and functionally diverse ligands, while the beta chain contains two tyrosine phosphorylation motifs that interact with adaptor and signaling proteins. This receptor is expressed by cells in the monocytic lineage, dendritic cells, hepatocytes, fibroblasts, adipocytes, neurons, and syncytiotrophoblasts. CD91 plays a crucial role in several cellular processes, including ligand endocytosis and trafficking to lysosomes, intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. It is involved in cross-presenting antigens via MHC class I molecules on antigen-presenting cells after endocytosis of heat shock protein-peptide complexes. Additionally, CD91 is essential for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of CD91 decreases with age and is found to be lower in brain tissue from Alzheimer patients compared to controls. The receptor also plays a role in cell migration and activating signaling cascades, highlighting its importance in both immune function and disease processes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: A2MR; alpha 2-macroglobulin receptor; Alpha-2-macroglobulin receptor; APOER; Apolipoprotein E receptor; CD91; FLJ16451; lipoprotein receptor-related protein; low density lipoprotein receptor-related protein 1; LRP-1; lrp1; MGC88725; Prolow-density lipoprotein receptor-related protein 1; TbetaR-V/LRP-1/IGFBP-3 receptor; type V tgf-beta receptor

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Gene Aliases: A2MR; AI316852; APOER; APR; b2b1554Clo; CD91; DDH3; IGFBP-3R; IGFBP3R; IGFBP3R1; KPA; LRP; LRP1; LRP1A; TGFBR5

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UniProt ID: (Human) Q07954, (Mouse) Q91ZX7

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Entrez Gene ID: (Human) 4035, (Mouse) 16971

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Function(s)
beta-amyloid binding RNA binding low-density lipoprotein receptor activity scavenger receptor activity calcium ion binding protein binding alpha-2 macroglobulin receptor activity apolipoprotein receptor activity clathrin heavy chain binding apolipoprotein binding signaling receptor activity cargo receptor activity heparan sulfate proteoglycan binding macromolecular complex binding metal ion binding lipoprotein particle receptor binding protease binding protein complex binding poly(A) RNA binding apolipoprotein extracellular matrix structural protein transmembrane signal receptor
Process(es)
retinoid metabolic process astrocyte activation involved in immune response lipid metabolic process endocytosis receptor-mediated endocytosis phagocytosis lysosomal transport enzyme linked receptor protein signaling pathway negative regulation of macromolecule metabolic process negative regulation of gene expression regulation of extracellular matrix disassembly positive regulation of cholesterol efflux negative regulation of smooth muscle cell migration regulation of endocytosis negative regulation of Wnt signaling pathway receptor internalization positive regulation of lipid transport regulation of actin cytoskeleton organization aorta morphogenesis lipoprotein transport apoptotic cell clearance transcytosis positive regulation of endocytosis positive regulation of transport regulation of protein metabolic process negative regulation of SMAD protein import into nucleus beta-amyloid clearance amyloid-beta clearance by transcytosis amyloid-beta clearance by cellular catabolic process transport across blood-brain barrier positive regulation of beta-amyloid clearance regulation of extracellular matrix organization positive regulation of reverse cholesterol transport positive regulation of protein localization to plasma membrane positive regulation of transcytosis cellular response to beta-amyloid positive regulation of lysosomal protein catabolic process negative regulation of platelet-derived growth factor receptor-beta signaling pathway protein kinase C-activating G-protein coupled receptor signaling pathway multicellular organism development cholesterol metabolic process cell proliferation negative regulation of neuron projection development regulation of cholesterol transport regulation of phospholipase A2 activity negative regulation of neuron apoptotic process positive regulation of protein transport
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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