Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: QDSRGCARW CPQNSSCVNA TACRCNPGFS SFSEIITTPT ETCDDINECA TPSKVSCGKF SDCWNTEGSY DCVCSPGYEP VSGAKTFKNE SENTCQDVDE CSSGQHQCDS STVCFNTVGS YSCRCRPGWK PRHGIPNNQK DTVCEDMTFS TWTPPPGVHS QTLSRFFDKV QDLGRDSKTS SAEVTIQNVI KLVDELMEAP GDVEALAPPV RHLIATQLLS NLEDIMRILA KSLPKGPFTY ISPSNTELTL MIQERGDKNV TMGQSSARMK LNWAVAAGAE DPGPAVAGIL SIQNMTTLLA NASLNLHSKK QAELEEIYES SIRGVQLRRL S (21-350 aa encoded by BC026690)
CD97 is a G-protein-coupled seven-span transmembrane adhesive receptor that is constitutively expressed on granulocytes and monocytes and rapidly upregulated on T and B cells upon activation. CD97 is produced in alternatively spliced forms and its cellular ligand is CD55 (DAF), which protects various cell types from complement-mediated damage. Interaction of CD97 on leukocytes and CD55 on vessel cells probably facilitate leukocyte activation and migration into the tissues, similarly, CD97 seems to play a role in tumour migration and invasiveness. CD97 is involved in T cell regulation and peripheral granulocyte homeostasis.
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Protein Aliases: Adhesion G protein-coupled receptor E5; CD97; CD97 molecule; Leukocyte antigen CD97; seven transmembrane helix receptor; seven-span transmembrane protein; seven-transmembrane, heterodimeric receptor associated with inflammation
Gene Aliases: ADGRE5; CD97; TM7LN1
UniProt ID: (Human) P48960
Entrez Gene ID: (Human) 976
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