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Invitrogen
CD97 Polyclonal Antibody
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FIGURE: 1 / 1
CD97 Antibody (PA5-120871) in WB
Western blot analysis of CD97 in extracts of various cell lines. Samples were incubated with CD97 Polyclonal antibody (Product # PA5-120871) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-120871
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 240-435 of human CD97 (NP_001775.2).
Conjugate
Form
Liquid
Concentration
0.82 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive test controls include: HepG2, Jurkat, Mouse lung, Rat liver. The target is usually found in the following locations: Cell membrane, Multi-pass membrane protein, Secreted, extracellular space.
Immunogen sequence: NLEDIMRILA KSLPKGPFTY ISPSNTELTL MIQERGDKNV TMGQSSARMK LNWAVAAGAE DPGPAVAGIL SIQNMTTLLA NASLNLHSKK QAELEEIYES SIRGVQLRRL SAVNSIFLSH NNTKELNSPI LFAFSHLESS DGEAGRDPPA KDVMPGPRQE LLCAFWKSDS DRGGHWATEG CQVLGSKNGS TTCQCS
Target Information
CD97 is a G-protein-coupled seven-span transmembrane adhesive receptor that is constitutively expressed on granulocytes and monocytes and rapidly upregulated on T and B cells upon activation. CD97 is produced in alternatively spliced forms and its cellular ligand is CD55 (DAF), which protects various cell types from complement-mediated damage. Interaction of CD97 on leukocytes and CD55 on vessel cells probably facilitate leukocyte activation and migration into the tissues, similarly, CD97 seems to play a role in tumour migration and invasiveness. CD97 is involved in T cell regulation and peripheral granulocyte homeostasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Adhesion G protein-coupled receptor E5; CD97; CD97 antigen; CD97 molecule; EGF-TM7 receptor; Leukocyte antigen CD97; seven transmembrane helix receptor; seven-span transmembrane protein; seven-transmembrane, heterodimeric receptor associated with inflammation
Gene Aliases: AA409984; ADGRE5; CD97; TM7LN1
UniProt ID: (Human) P48960, (Mouse) Q9Z0M6
Entrez Gene ID: (Human) 976, (Mouse) 26364, (Rat) 361383
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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