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AbboMax

CDC2 (CDK1) Polyclonal Antibody

View all (78) CDK1 antibodies

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CDC2 (CDK1) Polyclonal Antibody

Product Details

602-170

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-1 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

2-10 µg/mL
-
Product Specifications

Species Reactivity

Bovine, Chicken, Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide surrounding to the epitope -GTYGV- without a phosphorylation site at Tyr15 of human CDC2 protein
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with proprietary stabilizer

Contains

0.01% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Positive control: A431 cell lysate

Cellular location: Nuclear.

Target Information

CDK1 or Cell Division Control protein 1 is essential for the completion of START, the controlling event in the cell cycle that is required to initiate mitosis. CDK1 is a catalytic subunit of a protein kinase complex, called the M-Phase Promoting Factor that induces entry into mitosis and is universal among eukaryotes. Phosphorylation of Bcl-2 in G2/M phase-arrested cells following photodynamic therapy with hypericin involves a CDK1-mediated signal and delays the onset of apoptosis. Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer has also been demonstrated.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ABL1; CDK1; cell cycle controller CDC2; Cell division control protein 2 homolog; cell division cycle 2, G1 to S and G2 to M; Cell division protein kinase 1; Cyclin-dependent kinase 1; DKFZp686L20222; KCIP-1; MGC111195; MGC53829; OTTHUMP00000019660; P34 CDK1; P34 MGC111195; p34 protein kinase; Protein 1054; unnamed protein product

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Gene Aliases: CDC2; CDC28A; CDK1; CDKN1; P34CDC2

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UniProt ID: (Chicken) P13863, (Bovine) P48734, (Human) P06493

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Entrez Gene ID: (Chicken) 396252, (Bovine) 281061, (Human) 983

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Function(s)
protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity ATP binding RNA polymerase II carboxy-terminal domain kinase activity chromatin binding cyclin binding Hsp70 protein binding histone kinase activity protein kinase activity protein binding non-receptor serine/threonine protein kinase
Process(es)
G2/M transition of mitotic cell cycle double-strand break repair via homologous recombination protein phosphorylation mitotic G2 DNA damage checkpoint cellular response to heat regulation of circadian rhythm rhythmic process cell division apoptotic process cell proliferation positive regulation of G2/M transition of mitotic cell cycle histone phosphorylation peptidyl-serine phosphorylation peptidyl-threonine phosphorylation epithelial cell differentiation protein localization to kinetochore negative regulation of apoptotic process Golgi disassembly positive regulation of protein localization to nucleus positive regulation of mitochondrial ATP synthesis coupled electron transport G1/S transition of mitotic cell cycle regulation of transcription involved in G1/S transition of mitotic cell cycle activation of MAPK activity microtubule cytoskeleton organization DNA replication DNA repair protein complex assembly DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest mitotic nuclear division mitotic nuclear envelope disassembly centrosome cycle pronuclear fusion cell aging response to toxic substance positive regulation of gene expression regulation of Schwann cell differentiation response to organic cyclic compound response to amine response to activity cell migration chromosome condensation organ regeneration anaphase-promoting complex-dependent catabolic process positive regulation of protein import into nucleus, translocation response to drug protein ubiquitination involved in ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process response to ethanol positive regulation of DNA replication positive regulation of mitotic cell cycle regulation of embryonic development response to cadmium ion response to copper ion response to axon injury negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle ventricular cardiac muscle cell development positive regulation of cardiac muscle cell proliferation cellular response to hydrogen peroxide
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