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Invitrogen
CDC2L5 Polyclonal Antibody
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FIGURE: 1 / 3
CDC2L5 Antibody (PA5-99763) in ICC/IF
Immunocytochemistry analysis of CDC2L5 in A549 cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with CDC2L5 polyclonal antibody (Product # PA5-99763) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG(H+L) (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
Product Details
PA5-99763
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CDK13(Accession Q14004), corresponding to amino acid residues T670-Y720.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total CDK13.
Target Information
CDK13/cyclin K serine/threonine kinase is dimeric protein complex. CDK13 is a member of the cyclin-dependent serine/threonine protein kinase family. Members of this family are well known for their essential roles as master switches in cell cycle control. The exact function of this protein has not yet been determined, but it may play a role in mRNA processing and may be involved in regulation of hematopoiesis. Cyclin K is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain of the large subunit of RNA polymerase II.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CDC2-related protein kinase 5; cell division cycle 2-like 5 (cholinesterase-related cell division controller); Cell division cycle 2-like protein kinase 5; Cell division protein kinase 13; Cholinesterase-related cell division controller; Cyclin-dependent kinase 13; hCDK13
Gene Aliases: 2310015O17Rik; CDC2L; CDC2L5; CDK13; CHDFIDD; CHED; hCDK13; KIAA1791
UniProt ID: (Human) Q14004, (Mouse) Q69ZA1
Entrez Gene ID: (Human) 8621, (Mouse) 69562
nucleotide binding
RNA binding
protein kinase activity
protein serine/threonine kinase activity
cyclin-dependent protein serine/threonine kinase activity
protein binding
ATP binding
RNA polymerase II carboxy-terminal domain kinase activity
kinase activity
transferase activity
protein kinase binding
cyclin binding
protein serine kinase activity
transferase activity, transferring phosphorus-containing groups
poly(A) RNA binding
non-receptor serine/threonine protein kinase
alternative mRNA splicing, via spliceosome
mRNA processing
RNA splicing
regulation of signal transduction
hemopoiesis
positive regulation of transcription elongation from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase II promoter
regulation of cell cycle
negative regulation of stem cell differentiation
protein phosphorylation
phosphorylation
phosphorylation of RNA polymerase II C-terminal domain
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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