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Proteintech
CDC34 Polyclonal Antibody
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Product Details
10964-2-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CDC34 Fusion Protein Ag1438 (1-236 aa encoded by BC009850)
Conjugate
Form
Liquid
Concentration
0.24 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody can also recognize CDC34B (UBC3B) which is highly homologous to UBC3 (CDC34) with only 47 amino acid differences.
Immunogen sequence: MARPLVPSS QKALLLELKG LQEEPVEGFR VTLVDEGDLY NWEVAIFGPP NTYYEGGYFK ARLKFPIDYP YSPPAFRFLT KMWHPNIYET GDVCISILHP PVDDPQSGEL PSERWNPTQN VRTILLSVIS LLNEPNTFSP ANVDASVMYR KWKESKGKDR EYTDIIRKQV LGTKVDAERD GVKVPTTLAE YCVKTKAPAP DEGSDLFYDD YYEDGEVEEE ADSCFGDDED DSGTEES (1-236 aa encoded by BC009850)
Target Information
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Cooperates with the E2 UBCH5C and the SCF (FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Performs ubiquitin chain elongation building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. UBE2D3 acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Cooperates with the SCF (SKP2) E3 ligase complex to regulate cell proliferation through ubiquitination and degradation of MYBL2 and KIP1. Involved in ubiquitin conjugation and degradation of CREM isoform ICERIIgamma and ATF15 resulting in abrogation of ICERIIgamma- and ATF5-mediated repression of cAMP-induced transcription during both meiotic and mitotic cell cycles. Involved in the regulation of the cell cycle G2/M phase through its targeting of the WEE1 kinase for ubiquitination and degradation. Also involved in the degradation of beta-catenin. Is target of human herpes virus 1 protein ICP0, leading to ICP0-dependent dynamic interaction with proteasomes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: (E3-independent) E2 ubiquitin-conjugating enzyme R1; cell division cycle 34 homolog; E2 ubiquitin-conjugating enzyme R1; E2-CDC34; serine protease; ubiquitin carrier protein; ubiquitin conjugating enzyme E2 R1; ubiquitin-conjugating enzyme Cdc34; Ubiquitin-conjugating enzyme E2 R1; Ubiquitin-conjugating enzyme E2-32 kDa complementing; Ubiquitin-conjugating enzyme E2-CDC34; Ubiquitin-protein ligase R1
Gene Aliases: AI327276; CDC34; E2-CDC34; UBC3; UBCH3; UBE2R1
UniProt ID: (Human) P49427, (Mouse) Q8CFI2
Entrez Gene ID: (Human) 997, (Mouse) 216150, (Rat) 299602
protein polyubiquitination
cell cycle
protein ubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of neuron apoptotic process
negative regulation of cAMP-mediated signaling
protein K48-linked ubiquitination
positive regulation of inclusion body assembly
response to growth factor
G1/S transition of mitotic cell cycle
DNA replication initiation
cellular protein modification process
cellular response to interferon-beta
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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