This is a rabbit polyclonal antibody raised against part of C-terminus of human CDC45L.
Immunogen sequence: LWWAIVGLT DQWVQDKITQ MKYVTDVGVL QRHVSRHNHR NEDEENTLSV DCTRISFEYD LRLVLYQHWS LHDSLCNTSY TAARFKLWSV HGQKRLQEFL ADMGLPLKQV KQKFQAMDIS LKENLREMIE ESANKFGMKD MRVQTFSIHF GFKHKFLASD VVFATMSLME SPEKDGSGTD HFIQALDSLS RSNLDKLYHG LELAKKQLRA TQQTIASCLC TNLVISQGPF LYCSLMEGTP DVMLFSRPAS LSLLSKHLLK SFVCSTKNRR CKLLPLVMAA PLSMEHGTVT VVGIPPETDS SDRKNFFGRA FEKAAESTSS RMLHNHFDLS VIELKAEDRS KFLDALISLL S (217-566 aa encoded by BC010022)
The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Multiple polyadenylation sites of this gene are reported.
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Protein Aliases: CDC 45; CDC 45L; CDC45 cell division cycle 45 homolog; CDC45 like; CDC45-related protein; Cell division control protein 45 homolog; cell division cycle 45 homolog; cell division cycle 45-like 2; human CDC45; PORC PI 1; PORC-PI-1
Gene Aliases: CDC45; CDC45L; CDC45L2; PORC-PI-1; UNQ374/PRO710
Molecular Function: replication origin binding protein