Search
Invitrogen
CDC73 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
PA5-149015
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived recombinant human CDC73, Met1-Glu260
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
Cdc73 is a tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. Cdc73 is part of the PAF1 complex, a five-subunit protein complex composed of Paf1, Cdc73, Leo1, Rtf1 and Ctr9. PAF1 was first purified from yeast in association with RNA polymerase II and is believed to function in transcription elongation. The yeast PAF (yPAF) complex interacts with RNA polymerase II and coordinates the setting of histone marks associated with active transcription. In addition to coordinating events during transcription (initiation, promoter clearance, and elongation), hPAF also coordinates events in RNA quality control. Cdc73 may also be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: cell division cycle 73 Paf1/RNA polymerase II complex component homolog (S. cerevisiae) isoform CDC73_1; cell division cycle 73 Paf1/RNA polymerase II complex component homolog (S. cerevisiae) isoform CDC73_2; cell division cycle 73 Paf1/RNA polymerase II complex component-like protein; cell division cycle 73, Paf1/RNA polymerase II complex component, homolog; Cell division cycle protein 73 homolog; Familial isolated hyperparathyroidism; hyperparathyroidism 2 homolog; Hyperparathyroidism 2 protein; Hyperparathyroidism 2 protein homolog; Paf1/RNA polymerase II complex component; Parafibromin; unnamed protein product; Vcell division cycle 73, Paf1/RNA polymerase II complex component, homolog
Gene Aliases: 8430414L16Rik; BC027756; C130030P16Rik; C1orf28; C81219; CDC73; FIHP; HPTJT; HRPT1; HRPT2; HYX
UniProt ID: (Human) Q6P1J9, (Mouse) Q8JZM7
Entrez Gene ID: (Human) 79577, (Mouse) 214498
negative regulation of transcription from RNA polymerase II promoter
endodermal cell fate commitment
transcription, DNA-templated
mRNA polyadenylation
cell cycle
negative regulation of cell proliferation
histone monoubiquitination
Wnt signaling pathway
stem cell population maintenance
positive regulation of Wnt signaling pathway
positive regulation of mRNA 3'-end processing
protein destabilization
positive regulation of transcription elongation from RNA polymerase II promoter
histone H2B ubiquitination
negative regulation of myeloid cell differentiation
positive regulation of transcription from RNA polymerase II promoter
negative regulation of fibroblast proliferation
negative regulation of epithelial cell proliferation
cellular response to lipopolysaccharide
negative regulation of G1/S transition of mitotic cell cycle
regulation of cell growth
regulation of transcription from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
mRNA 3'-end processing
negative regulation of apoptotic process
positive regulation of cell cycle G1/S phase transition
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support