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Immunogen sequence: LKTVSSYSLQ RQSLLDMSLV KLQLCHMLVE PNLCRSVLIA NTVRQIQEEM TQDGTWRTVA PQAAERAPLD RLVSTEILCR A
Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 85%.
CDCA4 encodes a protein that belongs to the E2F family of transcription factors. This protein regulates E2F-dependent transcriptional activation and cell proliferation, mainly through the E2F/retinoblastoma protein pathway. It also functions in the regulation of JUN oncogene expression. This protein shows distinctive nuclear-mitotic apparatus distribution, it is involved in spindle organization from prometaphase, and may also play a role as a midzone factor involved in chromosome segregation or cytokinesis. Two alternatively spliced transcript variants encoding the same protein have been noted for this gene. Two pseudogenes have also been identified on chromosome 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Cell division cycle-associated protein 4; FLJ20764; Hematopoietic progenitor protein; MGC19517
Gene Aliases: CDCA4; HEPP; SEI-3/HEPP
UniProt ID: (Human) Q9BXL8
Entrez Gene ID: (Human) 55038
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