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Invitrogen
CDH11 Polyclonal Antibody
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Product Details
PA5-88399
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 120-400 of human CDH11 (NP_0017882)
Conjugate
Form
Liquid
Concentration
1.55 mg/mL
Amount
155 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: U-87MG, A-549, HT-29; Cellular Location: Cell membrane, Single-pass type I membrane protein
Immunogen sequence: ERAQYTLMAQ AVDRDTNRPL EPPSEFIVKV QDINDNPPEF LHETYHANVP ERSNVGTSVI QVTASDADDP TYGNSAKLVY SILEGQPYFS VEAQTGIIRT ALPNMDREAK EEYHVVIQAK DMGGHMGGLS GTTKVTITLT DVNDNPPKFP QSVYQMSVSE AAVPGEEVGR VKAKDPDIGE NGLVTYNIVD GDGMESFEIT TDYETQEGVI KLKKPVDFET KRAYSLKVEA ANVHIDPKFI SNGPFKDTVT VKISVEDADE PPMFLAPSYI HEVQENAAAG T
Target Information
This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. All cadherins are single-pass transmembrane proteins with a variable number of 110 amino acid extracellular cadherin (EC) domains. Classical cadherins contain five large N-terminal EC domains, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Based on amino acid alignment, classical cadherins are divided into type I and type II subgroups. Type I cadherins, including cadherins E (epithelial), N (neural), P (placental), and R (retinal) cadherin differ from type I cadherins in their specific amino acid sequences. Type II cadherins include human cadherin-5, -6, -8, -11, and -12. Type II cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Cadherin-11 (OB-Cadherin) is a marker of the loosely connected and migratory cellular elements of the mesenchyme. Strong expression of Cadherin-11 has been noted in brain, spinal cord, bone marrow and bone cells, and is regulated in human endometrial glandular epithelial and stromal cells. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. A variant Cadherin-11 gene (variant form) encodes a truncated protein with an unusual cytoplasmic domain not present in other cadherins. The variant protein is generated by alternative splicing, utilizing a 179 bp intronic sequence. Recently, Cadherin-11 mRNA and protein were found to be expressed in most invasive breast cancer cell lines tested but not in non-invasive cell lines, suggesting that Cadherin-11 may be a marker for aggressive, invasive tumor subsets.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cadherin; cadherin 11, type 2, OB-cadherin (osteoblast); Cadherin-11; OB Cadherin; OB-cadherin; OSF-4; Osteoblast cadherin; osteoblast-cadherin; unnamed protein product
Gene Aliases: Cad-11; CAD11; CDH11; CDHOB; ESWS; OB; OSF-4; TBHS2
UniProt ID: (Human) P55287, (Mouse) P55288
Entrez Gene ID: (Human) 1009, (Mouse) 12552
cell morphogenesis
skeletal system development
ossification
aortic valve formation
cell-cell junction assembly
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
cell migration
corticospinal tract morphogenesis
negative regulation of cell migration
cell-substrate adhesion
adherens junction organization
cell-cell adhesion mediated by cadherin
focal adhesion assembly
modulation of synaptic transmission
cell-cell adhesion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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