Immunogen sequence: KRREKERHTK QLLIDPEDDV RDNILKYDEE GGGEEDQDYD LSQLQQPEAM GHVPSKAPGV RRVDERPVGA EPQYPIRPMV PHPGDIGDFI NEGLRAADND PTAPPYDSLL VFDYEGSGST AGSVSSLNSS SSGDQDYDYL NDWGPRFKKL ADMYGGGEED; Positive Samples: HepG2, Mouse brain, Mouse thymus, Rat brain, Rat skeletal muscle; Cellular Location: Cell membrane, Single-pass type I membrane protein
CDH4 is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: Cadherin; cadherin 4 type 1 R-cadherin (retinal); cadherin 4, type 1, preproprotein; cadherin 4, type 1, R-cadherin (retinal); Cadherin-4; R-CAD; R-cadherin; retina cadherin; Retinal cadherin
Gene Aliases: AW120700; CAD4; CDH4; Cdh4l; R-CAD; R-Cadh; R-cadherin; RCAD
Molecular Function: cadherin