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Immunogen sequence: TLTVTLTDVN DNPPKFAQSL YHFSVPEDVV LGTAIGRVKA NDQDIGENAQ SSYDIIDGDG TALFEITSDA QAQDGIIRLR KPLDFETKKS YTLKVEAANV HIDPRFSGRG PFKDTAT
Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 98%.
CDH8 is a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CADH8; Cadherin; cadherin 8, type 2; Cadherin-8; Cadherin8
Gene Aliases: CDH8; Nbla04261
UniProt ID: (Human) P55286
Entrez Gene ID: (Human) 1006
Molecular Function:
cadherin
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