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Bioss
CDK11 Polyclonal Antibody
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Product Details
BS-3999R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human CDK11.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
CDK11 is a member of the cyclin-dependent kinase 11 family which is known to be essential for eukaryotic cell cycle control and it is in close proximity to CDC2L2, a nearly identical gene in the same chromosomal region. CDK11 is a negative regulator of normal cell cycle progression and Its expression is regulated during murine embryogenesis, and its activity is coordinately regulated with that of p34 (cdc2) during the cell cycle. CDK11 gene may harbor 1 or more tumor suppressor genes that affected by chromosome 1p36 modifications in neuroblastoma. CDK11 could be cleaved by caspases and was demonstrated to play roles in cell apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CDC-related protein kinase p58; cell division cycle 2 homolog-like 1; cell division cycle 2 homolog-like 2; cell division cycle 2-like 1; cell division cycle 2-like 1 (PITSLRE proteins); cell division cycle 2-like 2; cell division cycle 2-like 2 (PITSLRE proteins); Cell division cycle 2-like protein kinase 1; Cell division cycle 2-like protein kinase 2; Cell division protein kinase 11; Cell division protein kinase 11A; Cell division protein kinase 11B; CLK-1; Cyclin-dependent kinase 11; Cyclin-dependent kinase 11A; Cyclin-dependent kinase 11B; Galactosyltransferase-associated protein kinase p58/GTA; p58 CLK-1; PITSLRE B; PITSLRE protein kinase beta; PITSLRE proteins; PITSLRE serine/threonine-protein kinase CDC2L1; PITSLRE serine/threonine-protein kinase CDC2L2
Gene Aliases: AA989746; Cdc11b; CDC2L1; CDC2L2; CDC2L3; CDK11; CDK11-p110; CDK11-p46; CDK11-p58; CDK11A; CDK11B; CLK-1; p58; p58CDC2L1; p58CLK-1; p58GTA; PITSLRE; PITSLREA; PITSLREB; PK58
UniProt ID: (Human) Q9UQ88, (Human) Q9NZS5, (Mouse) P24788
Entrez Gene ID: (Human) 728642, (Human) 984, (Rat) 252879, (Mouse) 12537
protein kinase activity
protein serine/threonine kinase activity
cyclin-dependent protein serine/threonine kinase activity
ATP binding
protein binding
poly(A) RNA binding
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
regulation of cell growth
regulation of transcription, DNA-templated
protein phosphorylation
apoptotic process
mitotic nuclear division
regulation of mRNA processing
regulation of cell cycle
cell proliferation
blastocyst development
regulation of mitotic nuclear division
negative regulation of apoptotic signaling pathway
cell cycle
phosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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