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Invitrogen
CDK13 Polyclonal Antibody
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Product Details
PA5-27702
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human CDC2L5. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.83 mg/mL
Amount
83 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Raji.
Predicted reactivity: Mouse (87%), Rat (87%), Bovine (94%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
CDK13/cyclin K serine/threonine kinase is dimeric protein complex. CDK13 is a member of the cyclin-dependent serine/threonine protein kinase family. Members of this family are well known for their essential roles as master switches in cell cycle control. The exact function of this protein has not yet been determined, but it may play a role in mRNA processing and may be involved in regulation of hematopoiesis. Cyclin K is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain of the large subunit of RNA polymerase II.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CDC2-related protein kinase 5; Cell division cycle 2-like protein kinase 5; Cell division protein kinase 13; Cholinesterase-related cell division controller; Cyclin-dependent kinase 13; hCDK13
Gene Aliases: CDC2L; CDC2L5; CDK13; CHDFIDD; CHED; hCDK13; KIAA1791
UniProt ID: (Human) Q14004
Entrez Gene ID: (Human) 8621
nucleotide binding
RNA binding
protein kinase activity
protein serine/threonine kinase activity
cyclin-dependent protein serine/threonine kinase activity
protein binding
ATP binding
RNA polymerase II carboxy-terminal domain kinase activity
kinase activity
transferase activity
protein kinase binding
cyclin binding
protein serine kinase activity
alternative mRNA splicing, via spliceosome
mRNA processing
RNA splicing
regulation of signal transduction
hemopoiesis
positive regulation of transcription elongation from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase II promoter
regulation of cell cycle
negative regulation of stem cell differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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