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Proteintech
CDK2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
10122-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CDK2 Fusion Protein Ag0166 (8-210 aa encoded by BC003065)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.4 mg/mL
Amount
60 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: EKIGEGTYG VVYKARNKLT GEVVALKKIR LDTETEGVPS TAIREISLLK ELNHPNIVKL LDVIHTENKL YLVFEFLHQD LKKFMDASAL TGIPLPLIKS YLFQLLQGLA FCHSHRVLHR DLKPQNLLIN TEGAIKLADF GLARAFGVPV RTYTHEVVTL WYRAPEILLG CKYYSTAVDI WSLGCIFAEM VTRRALFPGD SEID (8-210 aa encoded by BC003065)
Target Information
CDK2/cyclinO is a member of the cyclin dependent protein kinase family complexed to CyclinO. CyclinO was used as a specific protein isoform name for the UNG gene which is localized exclusively in the nucleus. In addition, CyclinO was reported to shows significant uracil-DNA glycosylase activity. CDK2/cyclinO protein levels increase during G1 phase and the protein is turned over during the course of cell cycle. The levels of cyclin A-cdk2 is maximal at the G1/S transition and both cdk2 and cyclin A are found associated with DNA in the initiation complex during replication. Rb protein acts as substrate for cdk2-cyclin E and/or cdk2-cyclin A in vivo. Cdk2 is activated and specifically localized to the nucleus during late G1-, S-, and G2-phase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cdc2-related protein kinase; CDC28; CDC2A; CDK1; CDK2; cell division protein kinase 2; cyclin dependent kinase 2-alpha; EC 2.7.11.22; EC 2.7.11.23; kinase Cdc2; MPF; p33 protein kinase; p33CDK2; p34 protein kinase; unnamed protein product
Gene Aliases: A630093N05Rik; CDKN2; p33(CDK2)
UniProt ID: (Human) P24941, (Mouse) P97377
Entrez Gene ID: (Human) 1017, (Rat) 362817, (Mouse) 12566
magnesium ion binding
protein kinase activity
protein serine/threonine kinase activity
cyclin-dependent protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
protein domain specific binding
cyclin binding
histone kinase activity
cyclin-dependent protein kinase activity
protein serine kinase activity
macromolecular complex binding
G1/S transition of mitotic cell cycle
G2/M transition of mitotic cell cycle
negative regulation of transcription from RNA polymerase II promoter
lens development in camera-type eye
chromatin remodeling
protein phosphorylation
potassium ion transport
cellular response to DNA damage stimulus
centriole replication
signal transduction
Ras protein signal transduction
positive regulation of cell proliferation
response to xenobiotic stimulus
response to toxic substance
peptidyl-serine phosphorylation
positive regulation of heterochromatin assembly
positive regulation of DNA-dependent DNA replication initiation
response to estradiol
cellular response to insulin stimulus
negative regulation of protein catabolic process
telomere maintenance in response to DNA damage
post-translational protein modification
response to ethanol
positive regulation of transcription, DNA-templated
response to cadmium ion
response to cAMP
response to electrical stimulus
liver regeneration
negative regulation of protein localization to chromatin
regulation of heterochromatin organization
positive regulation of meiotic cell cycle process involved in oocyte maturation
DNA synthesis involved in mitotic DNA replication
DNA replication
regulation of mitotic cell cycle
mitotic G1 DNA damage checkpoint
positive regulation of DNA replication
centrosome duplication
meiotic cell cycle
cellular response to nitric oxide
cellular senescence
regulation of anaphase-promoting complex-dependent catabolic process
telomere maintenance
protection from non-homologous end joining at telomere
regulation of cell cycle
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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