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Proteintech
CDK2 Polyclonal Antibody, CoraLite® Plus 555
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FIGURE: 1 / 1
CDK2 Antibody (CL555-10122) in Flow
1X10^6 A431 cells were intracellularly stained with 0.5 µg CoraLite® Plus 555 Anti-Human CDK2 (CL555-10122) (red), or 0.5 µg CL555 Rabbit Isotype Control(CL555-30000)(blue). Cells were fixed and permeabilized with Transcription Factor Staining Buffer Kit (PF00011).
Product Details
CL555-10122
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
554/570 nm
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
PBS with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: EKIGEGTYGV VYKARNKLTG EVVALKKIRL DTETEGVPST AIREISLLKE LNHPNIVKLL DVIHTENKLY LVFEFLHQDL KKFMDASALT GIPLPLIKSY LFQLLQGLAF CHSHRVLHRD LKPQNLLINT EGAIKLADFG LARAFGVPVR TYTHEVVTLW YRAPEILLGC KYYSTAVDIW SLGCIFAEMV TRRALFPGDS EID
Target Information
CDK2/cyclinO is a member of the cyclin dependent protein kinase family complexed to CyclinO. CyclinO was used as a specific protein isoform name for the UNG gene which is localized exclusively in the nucleus. In addition, CyclinO was reported to shows significant uracil-DNA glycosylase activity. CDK2/cyclinO protein levels increase during G1 phase and the protein is turned over during the course of cell cycle. The levels of cyclin A-cdk2 is maximal at the G1/S transition and both cdk2 and cyclin A are found associated with DNA in the initiation complex during replication. Rb protein acts as substrate for cdk2-cyclin E and/or cdk2-cyclin A in vivo. Cdk2 is activated and specifically localized to the nucleus during late G1-, S-, and G2-phase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cdc2-related protein kinase; CDC28; CDC2A; CDK1; CDK2; Cell division protein kinase 2; cyclin dependent kinase 2-alpha; Cyclin-dependent kinase 2; EC 2.7.11.22; EC 2.7.11.23; kinase Cdc2; MPF; p33 protein kinase; p33CDK2; p34 protein kinase; unnamed protein product
Gene Aliases: A630093N05Rik; CDK2; CDKN2; p33(CDK2)
UniProt ID: (Human) P24941, (Mouse) P97377
Entrez Gene ID: (Human) 1017, (Rat) 362817, (Mouse) 12566
nucleotide binding
magnesium ion binding
protein kinase activity
protein serine/threonine kinase activity
cyclin-dependent protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
protein domain specific binding
cyclin binding
histone kinase activity
metal ion binding
cyclin-dependent protein kinase activity
protein serine kinase activity
protein complex binding
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
G1/S transition of mitotic cell cycle
G2/M transition of mitotic cell cycle
negative regulation of transcription from RNA polymerase II promoter
telomere maintenance
DNA replication
DNA repair
chromatin remodeling
transcription, DNA-templated
protein phosphorylation
potassium ion transport
cellular response to DNA damage stimulus
centriole replication
signal transduction
Ras protein signal transduction
regulation of mitotic cell cycle
positive regulation of cell proliferation
regulation of G2/M transition of mitotic cell cycle
regulation of gene expression
peptidyl-serine phosphorylation
positive regulation of heterochromatin assembly
mitotic G1 DNA damage checkpoint
protection from non-homologous end joining at telomere
positive regulation of DNA-dependent DNA replication initiation
telomere maintenance in response to DNA damage
post-translational protein modification
positive regulation of DNA replication
positive regulation of transcription, DNA-templated
centrosome duplication
cell division
meiotic cell cycle
cellular response to nitric oxide
cellular senescence
regulation of anaphase-promoting complex-dependent catabolic process
lens development in camera-type eye
mitotic nuclear division
response to toxic substance
histone phosphorylation
organ regeneration
response to estradiol
cellular response to insulin stimulus
response to drug
response to ethanol
response to cadmium ion
response to cAMP
response to electrical stimulus
regulation of cell cycle
regulation of gene silencing
cell cycle
phosphorylation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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