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          • Primary Antibodies ›
          • CDK5 Antibodies

          Invitrogen

          CDK5 Polyclonal Antibody

          Advanced Verification
          View all (26) CDK5 antibodies

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          Cite CDK5 Polyclonal Antibody

          Additional Information:
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          • Antibody Testing Data (5)
          • Advanced Verification (1)
          CDK5 Antibody in Immunocytochemistry (ICC/IF)
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          CDK5 Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.

          FIGURE: 1 / 6

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          CDK5 Antibody (PA5-96409) in ICC/IF

          Immunofluorescence analysis of CDK5 in U2OS cells. Samples were incubated with CDK5 Polyclonal antibody (Product # PA5-96409). Blue: DAPI for nuclear staining. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
          Published figure supplied by benchsci-logo
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          View Product

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          CDK5 Antibody in Immunocytochemistry (ICC/IF)
          CDK5 Antibody in Western Blot (WB)
          CDK5 Antibody in Western Blot (WB)
          CDK5 Antibody in Western Blot (WB)
          CDK5 Antibody in Immunoprecipitation (IP)
          CDK5 Antibody
          CDK5 Polyclonal Antibody

          Product Details

          PA5-96409

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:1,000
          -

          Immunocytochemistry (ICC/IF)

          1:10-1:100
          -

          ELISA (ELISA)

          1 µg/mL
          -

          Immunoprecipitation (IP)

          0.5 µg-4 µg antibody for 200 µg-400 µg extracts of
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Recombinant fusion protein containing a sequence corresponding to amino acids 1-292 of human CDK5 (NP_004926.1).
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.54 mg/mL

          Purification

          Affinity Chromatography

          Storage buffer

          PBS, pH 7.3, with 50% glycerol

          Contains

          0.09% sodium azide

          Storage conditions

          -20°C, Avoid Freeze/Thaw Cycles

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2808211

          Product Specific Information

          Immunogen sequence: MQKYEKLEKI GEGTYGTVFK AKNRETHEIV ALKRVRLDDD DEGVPSSALR EICLLKELKH KNIVRLHDVL HSDKKLTLVF EFCDQDLKKY FDSCNGDLDP EIVKSFLFQL LKGLGFCHSR NVLHRDLKPQ NLLINRNGEL KLADFGLARA FGIPVRCYSA EVVTLWYRPP DVLFGAKLYS TSIDMWSAGC IFAELANAGR PLFPGNDVDD QLKRIFRLLG TPTEEQWPSM TKLPDYKPYP MYPATTSLVN VVPKLNATGR DLLQNLLKCN PVQRISAEEA LQHPYFSDFC PP

          Positive Samples: 293T, HepG2, BT-474, Mouse brain, PC-12, Rat brain; Cellular Location: Cell junction, Cell membrane, Cell projection, Cytoplasm, Nucleus, Perikaryon, Peripheral membrane protein, growth cone, lamellipodium, postsynaptic cell membrane, postsynaptic density, synapse

          Target Information

          CDK5 is a member of the Cyclin-Dependent Kinase family that is most abundant in the mammalian brain. Active form of CDK5, which has also been called neuronal cdc2-like kinase, is a heterodimer of CDK5 and a 25 kDa protein which is derived proteolytically from a 35 kDa brain and neuron-specific protein and is essential for the kinase activity of CDK5. CDK5 has emerged as a crucial regulator of neuronal migration in the developing central nervous system. CDK5 phosphorylates a diverse list of substrates, implicating it in the regulation of a range of cellular processes - from adhesion and motility, to synaptic plasticity and drug addiction.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: CDK5; CDK5 activator 1; CDK5-SV; Cell division protein kinase 5; CR6 protein kinase; Cyclin-dependent kinase 5; Cyclin-dependent-like kinase 5; epididymis secretory sperm binding protein; protein kinase CDK5 splicing; Serine/threonine-protein kinase PSSALRE; Tau protein kinase II catalytic subunit; TPKII catalytic subunit

          View more View less

          Gene Aliases: AW048668; CDK5; CDKN5; Crk6; LIS7; PSSALRE

          View more View less

          UniProt ID: (Human) Q00535, (Mouse) P49615, (Rat) Q03114

          View more View less

          Entrez Gene ID: (Human) 1020, (Mouse) 12568, (Rat) 140908

          View more View less

          Function(s)
          nucleotide binding p53 binding protein kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity ErbB-2 class receptor binding protein binding ATP binding microtubule binding kinase activity transferase activity receptor inhibitor activity acetylcholine receptor activator activity ionotropic glutamate receptor binding ErbB-3 class receptor binding tau protein binding tau-protein kinase activity Hsp90 protein binding protein serine kinase activity cytoskeletal protein binding transferase activity, transferring phosphorus-containing groups protein kinase binding ephrin receptor binding non-receptor serine/threonine protein kinase
          Process(es)
          microtubule cytoskeleton organization neuron migration synaptic transmission, dopaminergic intracellular protein transport apoptotic process cell-matrix adhesion chemical synaptic transmission nervous system development axonogenesis synapse assembly skeletal muscle tissue development motor neuron axon guidance associative learning visual learning Schwann cell development synaptic vesicle exocytosis regulation of macroautophagy cell migration sensory perception of pain telencephalon development cerebellum development cerebellar cortex development cerebellar cortex formation hippocampus development layer formation in cerebral cortex central nervous system neuron development cerebral cortex development corpus callosum development actin cytoskeleton organization neuron differentiation regulation of cell migration negative regulation of axon extension forebrain development neuron projection development negative regulation of protein ubiquitination negative regulation of synaptic plasticity receptor catabolic process synaptic transmission, glutamatergic protein localization to synapse response to cocaine regulation of apoptotic process receptor clustering positive regulation of neuron apoptotic process negative regulation of cell cycle negative regulation of proteolysis negative regulation of transcription, DNA-templated positive regulation of calcium ion-dependent exocytosis negative regulation of protein export from nucleus behavioral response to cocaine regulation of synaptic plasticity synaptic vesicle endocytosis synaptic vesicle transport rhythmic process axon extension oligodendrocyte differentiation dendrite morphogenesis cell division neuron apoptotic process establishment of localization in cell regulation of cell cycle regulation of synaptic transmission, glutamatergic regulation of postsynaptic membrane potential excitatory postsynaptic potential regulation of dendritic spine morphogenesis calcium ion import positive regulation of protein targeting to membrane positive regulation of presynaptic cytosolic calcium concentration regulation of cell cycle phase transition regulation of protein localization to plasma membrane negative regulation of calcium ion-dependent exocytosis of neurotransmitter regulation of synaptic vesicle recycling cellular response to beta-amyloid protein phosphorylation exocytosis nucleocytoplasmic transport cell cycle response to wounding phosphorylation peptidyl-serine phosphorylation peptidyl-threonine phosphorylation cortical actin cytoskeleton organization positive regulation of protein binding serine phosphorylation of STAT3 protein regulated exocytosis positive regulation of protein kinase activity protein autophosphorylation neuron projection morphogenesis negative regulation of neuron death positive regulation of receptor activity central nervous system development
          It has to be done as per old AB suggested Products section.

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