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Invitrogen

CDK5 Polyclonal Antibody

View all (31) CDK5 antibodies

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CDK5 Polyclonal Antibody

Product Details

PA5-97571

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:5,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

Assay-Dependent
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Human Cyclin-dependent-like kinase 5 protein (1-292AA)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

3 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.03% ProClin 300

Storage conditions

-20°C or -80°C if preferred

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2812186

Target Information

CDK5 is a member of the Cyclin-Dependent Kinase family that is most abundant in the mammalian brain. Active form of CDK5, which has also been called neuronal cdc2-like kinase, is a heterodimer of CDK5 and a 25 kDa protein which is derived proteolytically from a 35 kDa brain and neuron-specific protein and is essential for the kinase activity of CDK5. CDK5 has emerged as a crucial regulator of neuronal migration in the developing central nervous system. CDK5 phosphorylates a diverse list of substrates, implicating it in the regulation of a range of cellular processes - from adhesion and motility, to synaptic plasticity and drug addiction.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CDK5; CDK5 activator 1; CDK5-SV; Cell division protein kinase 5; CR6 protein kinase; Cyclin-dependent kinase 5; Cyclin-dependent-like kinase 5; epididymis secretory sperm binding protein; protein kinase CDK5 splicing; Serine/threonine-protein kinase PSSALRE; Tau protein kinase II catalytic subunit; TPKII catalytic subunit

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Gene Aliases: AW048668; CDK5; CDKN5; Crk6; LIS7; PSSALRE

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UniProt ID: (Human) Q00535, (Mouse) P49615

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Entrez Gene ID: (Human) 1020, (Mouse) 12568

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Function(s)
nucleotide binding p53 binding protein kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity ErbB-2 class receptor binding protein binding ATP binding microtubule binding kinase activity transferase activity receptor inhibitor activity acetylcholine receptor activator activity ionotropic glutamate receptor binding ErbB-3 class receptor binding tau protein binding tau-protein kinase activity Hsp90 protein binding protein serine kinase activity cytoskeletal protein binding transferase activity, transferring phosphorus-containing groups protein kinase binding ephrin receptor binding non-receptor serine/threonine protein kinase
Process(es)
microtubule cytoskeleton organization neuron migration synaptic transmission, dopaminergic intracellular protein transport apoptotic process cell-matrix adhesion chemical synaptic transmission nervous system development axonogenesis synapse assembly skeletal muscle tissue development motor neuron axon guidance associative learning visual learning Schwann cell development synaptic vesicle exocytosis regulation of macroautophagy cell migration sensory perception of pain telencephalon development cerebellum development cerebellar cortex development cerebellar cortex formation hippocampus development layer formation in cerebral cortex central nervous system neuron development cerebral cortex development corpus callosum development actin cytoskeleton organization neuron differentiation regulation of cell migration negative regulation of axon extension forebrain development neuron projection development negative regulation of protein ubiquitination negative regulation of synaptic plasticity receptor catabolic process synaptic transmission, glutamatergic protein localization to synapse response to cocaine regulation of apoptotic process receptor clustering positive regulation of neuron apoptotic process negative regulation of cell cycle negative regulation of proteolysis negative regulation of transcription, DNA-templated positive regulation of calcium ion-dependent exocytosis negative regulation of protein export from nucleus behavioral response to cocaine regulation of synaptic plasticity synaptic vesicle endocytosis synaptic vesicle transport rhythmic process axon extension oligodendrocyte differentiation dendrite morphogenesis cell division neuron apoptotic process establishment of localization in cell regulation of cell cycle regulation of synaptic transmission, glutamatergic regulation of postsynaptic membrane potential excitatory postsynaptic potential regulation of dendritic spine morphogenesis calcium ion import positive regulation of protein targeting to membrane positive regulation of presynaptic cytosolic calcium concentration regulation of cell cycle phase transition regulation of protein localization to plasma membrane negative regulation of calcium ion-dependent exocytosis of neurotransmitter regulation of synaptic vesicle recycling cellular response to beta-amyloid protein phosphorylation exocytosis nucleocytoplasmic transport cell cycle response to wounding phosphorylation peptidyl-serine phosphorylation peptidyl-threonine phosphorylation cortical actin cytoskeleton organization positive regulation of protein binding serine phosphorylation of STAT3 protein regulated exocytosis positive regulation of protein kinase activity protein autophosphorylation neuron projection morphogenesis negative regulation of neuron death positive regulation of receptor activity
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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