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Invitrogen

CDK5 Polyclonal Antibody

View all (29) CDK5 antibodies

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CDK5 Polyclonal Antibody

Product Details

PA5-97571

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:5,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

Assay-Dependent
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Human Cyclin-dependent-like kinase 5 protein (1-292AA)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

3 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.03% ProClin 300

Storage conditions

-20°C or -80°C if preferred

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2812186

Target Information

CDK5 is a member of the Cyclin-Dependent Kinase family that is most abundant in the mammalian brain. Active form of CDK5, which has also been called neuronal cdc2-like kinase, is a heterodimer of CDK5 and a 25 kDa protein which is derived proteolytically from a 35 kDa brain and neuron-specific protein and is essential for the kinase activity of CDK5. CDK5 has emerged as a crucial regulator of neuronal migration in the developing central nervous system. CDK5 phosphorylates a diverse list of substrates, implicating it in the regulation of a range of cellular processes - from adhesion and motility, to synaptic plasticity and drug addiction.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CDK5; CDK5 activator 1; CDK5-SV; cell division protein kinase 5; CR6 protein kinase; cyclin-dependent-like kinase 5; epididymis secretory sperm binding protein; protein kinase CDK5 splicing; serine/threonine-protein kinase PSSALRE; tau protein kinase II catalytic subunit; TPKII catalytic subunit; unnamed protein product

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Gene Aliases: Crk6; LIS7; PSSALRE

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UniProt ID: (Human) Q00535, (Mouse) P49615

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Entrez Gene ID: (Human) 1020, (Mouse) 12568

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Function(s)
p53 binding protein kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity ErbB-2 class receptor binding protein binding ATP binding microtubule binding kinase activity receptor inhibitor activity acetylcholine receptor activator activity ionotropic glutamate receptor binding ErbB-3 class receptor binding tau protein binding tau-protein kinase activity Hsp90 protein binding protein serine kinase activity cytoskeletal protein binding protein kinase binding histone kinase activity ephrin receptor binding
Process(es)
neuron migration positive regulation of protein phosphorylation synaptic transmission, dopaminergic chromatin remodeling protein phosphorylation intracellular protein transport exocytosis nucleocytoplasmic transport apoptotic process muscle contraction cellular response to DNA damage stimulus mitochondrion organization cell-matrix adhesion axonogenesis synapse assembly skeletal muscle tissue development neuromuscular junction development motor neuron axon guidance associative learning visual learning Schwann cell development cell migration regulation of calcium ion-dependent exocytosis peptidyl-serine phosphorylation peptidyl-threonine phosphorylation sensory perception of pain telencephalon development cerebellum development cerebellar cortex development cerebellar cortex formation hippocampus development layer formation in cerebral cortex central nervous system neuron development cerebral cortex development corpus callosum development neuron differentiation regulation of cell migration negative regulation of axon extension cortical actin cytoskeleton organization forebrain development neuron projection development negative regulation of protein ubiquitination negative regulation of synaptic plasticity receptor catabolic process positive regulation of glial cell apoptotic process synaptic transmission, glutamatergic protein localization to synapse response to cocaine serine phosphorylation of STAT protein receptor clustering positive regulation of neuron apoptotic process regulated exocytosis negative regulation of cell cycle positive regulation of protein kinase activity negative regulation of proteolysis negative regulation of transcription, DNA-templated positive regulation of calcium ion-dependent exocytosis protein autophosphorylation negative regulation of protein export from nucleus behavioral response to cocaine regulation of synaptic plasticity synaptic vesicle endocytosis synaptic vesicle transport oligodendrocyte differentiation neuron projection morphogenesis dendrite morphogenesis negative regulation of transport neuron apoptotic process regulation of cell cycle regulation of synaptic transmission, glutamatergic regulation of postsynaptic membrane potential excitatory postsynaptic potential muscle tissue development regulation of dendritic spine morphogenesis calcium ion import positive regulation of protein targeting to membrane regulation of presynaptic cytosolic calcium ion concentration positive regulation of presynaptic cytosolic calcium concentration regulation of cell cycle phase transition regulation of protein localization to plasma membrane negative regulation of calcium ion-dependent exocytosis of neurotransmitter cellular response to beta-amyloid regulation of synapse pruning microtubule cytoskeleton organization chemical synaptic transmission synaptic vesicle exocytosis regulation of macroautophagy actin cytoskeleton organization regulation of apoptotic process axon extension establishment of localization in cell regulation of synaptic vesicle recycling
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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