This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated. View Details
MA5-11291 targets Cdk5 in IF, IP, and WB applications and shows reactivity with Human, mouse, and Rat samples.
The MA5-11291 immunogen is recombinant cdk5 protein.
Cyclin-dependent kinase-5 (CDK5) is a member of the cyclin-dependent kinase family of serine/threonine kinases. Its mRNA and protein are expressed in the kidneys, testes, and ovaries. And Its activity has been detected almost exclusively in brain extracts. Similar to other Cdks, monomeric Cdk5 displays no enzymatic activity; however, Cdk5 is not activated bycyclins. Instead, Cdk5 activity requires association with one of two brain-specific regulatory subunits, called p35 and p39. These two activators regulate the spatial and temporal expression of active Cdk5, restricting its activity primarily to post-mitotic neurons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CDK5-SV; Cell division protein kinase 5; CR6 protein kinase; CRK6; cyclin-dependent kinase 5; Cyclin-dependent-like kinase 5; protein kinase CDK5 splicing; Serine/threonine-protein kinase PSSALRE; Tau protein kinase II catalytic subunit; TPKII catalytic subunit
Gene Aliases: AW048668; CDK5; CDKN5; Crk6; LIS7; PSSALRE
Molecular Function: non-receptor serine/threonine protein kinase