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CDK5RAP1 Antibody (PA5-90755) in IHC (P)
Immunohistochemistry analysis of CDK5RAP1 in paraffin-embedded human colon carcinoma. Samples were incubated with CDK5RAP1 Polyclonal antibody (Product # PA5-90755) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-90755
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human CDK5RAP1 (NP_0574922)
Conjugate
Form
Liquid
Concentration
3.73 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2806223
Product Specific Information
Immunogen sequence: MHPLQCVLQV QRSLGWGPLA SVSWLSLRMC RAHSSLSSTM CPSPERQEDG ARKDFSSRLA AGPTFQHFLK SASAPQEKLS SEVEDPPPYL MMDELLGRQR KVYLETYGCQ MNVNDTEIAW SILQKSGYLR TSNLQEADVI LLVTCSIREK AEQTIWNRLH QLKALKTRRP RSRVPLRIGI LGCMAERLKE EILNREKMVD ILAGPDAYRD LPRLLAVAES GQQAANVLLS LDETYADVMP VQTSASATSA FVSIMRGCDN MCSYCIVPFT RGRERSRPIA SILEEVKKLS EQGLKEVTLL GQNVNSFRDN SEVQFNSAVP TNLSRGFTTN YKTKQGGLRF AHLLDQVSRV; Positive Samples: A-549, Mouse thymus
Target Information
Neuronal CDC2-like kinase, which is involved in the regulation of neuronal differentiation, is composed of a catalytic subunit, CDK5, and an activating subunit, p25NCK5A. The protein encoded by this gene binds to p25NCK5A and therefore may be involved in neuronal differentiation. Multiple transcript variants exist for this gene, but the full-length natures of only two have been determined.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CDK5 activator-binding protein C42; CDK5 regulatory subunit-associated protein 1; CDK5RAP1.3; CDK5RAP1.4; Mitochondrial tRNA methylthiotransferase CDK5RAP1; mt-tRNA-2-methylthio-N6-dimethylallyladenosine synthase; mt-tRNA-N6-(dimethylallyl)adenosine(37) methylthiotransferase
Gene Aliases: 2310066P17Rik; C20orf34; C42; CDK5RAP1; CGI-05; HSPC167
UniProt ID: (Human) Q96SZ6, (Rat) Q9JLH6, (Mouse) Q8BTW8
Entrez Gene ID: (Human) 51654, (Rat) 252827, (Mouse) 66971
brain development
tRNA methylthiolation
regulation of neuron differentiation
negative regulation of cyclin-dependent protein serine/threonine kinase activity
regulation of cyclin-dependent protein serine/threonine kinase activity
tRNA modification
cell proliferation
regulation of protein kinase activity
RNA modification
macromolecule modification
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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