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CDK5RAP3 Antibody (PA5-115000) in ICC/IF
Immunocytochemistry analysis of CDK5RAP3 in A549 cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115000). Secondary staining was applied with mouse anti-beta tubulin (1 hr at 37°, AlexaFluor 594 conjugated goat anti-rabbit IgG (Red), AlexaFluor 488 conjugated goat anti-mouse IgG (Green) and DAPI.
Product Details
PA5-115000
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CDK5RAP3(Accession Q96JB5), corresponding to amino acid residues I292-D315.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
RRID
AB_2899636
Target Information
This gene encodes a protein that has been reported to function in signaling pathways governing transcriptional regulation and cell cycle progression. It may play a role in tumorigenesis and metastasis. A pseudogene of this gene is located on the long arm of chromosome 20. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, May 2013].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CDK5 activator-binding protein C53; CDK5 activator-binding protein C53; CDK5 regulatory subunit associated protein IC53-2; CDK5 regulatory subunit-associated protein 3; IC53-2; ischemic heart CDK5 activator-binding protein C53; LXXLL/leucine-zipper-containing ARF-binding protein; LXXLL/leucine-zipper-containing ARFbinding protein; Protein HSF-27
Gene Aliases: 1810007E24Rik; BC002318; C53; C81486; CDK5RAP3; HSF-27; IC53; LZAP; MST016; MSTP016; OK/SW-cl.114; PP1553
UniProt ID: (Human) Q9H8G0, (Mouse) Q99LM2
Entrez Gene ID: (Human) 80279, (Rat) 80278, (Mouse) 80280
regulation of cyclin-dependent protein serine/threonine kinase activity
negative regulation of protein phosphorylation
mitotic G2 DNA damage checkpoint
brain development
cell proliferation
regulation of phosphatase activity
apoptotic nuclear changes
endoplasmic reticulum unfolded protein response
positive regulation of protein ubiquitination
negative regulation of NF-kappaB transcription factor activity
negative regulation of MAP kinase activity
negative regulation of protein kinase activity by regulation of protein phosphorylation
mitotic G2/M transition checkpoint
regulation of neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
protein ufmylation
negative regulation of protein serine/threonine kinase activity
positive regulation of protein localization to nucleus
positive regulation of signal transduction by p53 class mediator
negative regulation of cellular protein catabolic process
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
regulation of mitotic cell cycle
regulation of signal transduction involved in mitotic G2 DNA damage checkpoint
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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